The genetic background of the associations between sense of coherence and mental health, self-esteem and personality

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dc.contributor.author Silventoinen, K
dc.contributor.author Vuoksimaa, E
dc.contributor.author Volanen, SM
dc.contributor.author Palviainen, T
dc.contributor.author Rose, RJ
dc.contributor.author Suominen, S
dc.contributor.author Kaprio, J
dc.date.accessioned 2021-11-22T12:11:01Z
dc.date.available 2021-11-22T12:11:01Z
dc.date.issued 2021-05
dc.identifier.citation Silventoinen , K , Vuoksimaa , E , Volanen , SM , Palviainen , T , Rose , RJ , Suominen , S & Kaprio , J 2021 , ' The genetic background of the associations between sense of coherence and mental health, self-esteem and personality ' , Social Psychiatry and Psychiatric Epidemiology . https://doi.org/10.1007/s00127-021-02098-6
dc.identifier.other PURE: 170522542
dc.identifier.other PURE UUID: a846ea96-16c2-42eb-ba06-0982424df009
dc.identifier.other RIS: urn:BF832A533EA9B308277226B377D93F7B
dc.identifier.other WOS: 000652087700001
dc.identifier.other ORCID: /0000-0003-1759-3079/work/103593745
dc.identifier.other ORCID: /0000-0002-6534-3667/work/103593980
dc.identifier.other ORCID: /0000-0002-7847-8384/work/103595437
dc.identifier.uri http://hdl.handle.net/10138/336590
dc.description.abstract Purpose Sense of coherence (SOC) represents coping and can be considered an essential component of mental health. SOC correlates with mental health and personality, but the background of these associations is poorly understood. We analyzed the role of genetic factors behind the associations of SOC with mental health, self-esteem and personality using genetic twin modeling and polygenic scores (PGS). Methods Information on SOC (13-item Orientation of Life Questionnaire), four mental health indicators, self-esteem and personality (NEO Five Factor Inventory Questionnaire) was collected from 1295 Finnish twins at 20-27 years of age. Results In men and women, SOC correlated negatively with depression, alexithymia, schizotypal personality and overall mental health problems and positively with self-esteem. For personality factors, neuroticism was associated with weaker SOC and extraversion, agreeableness and conscientiousness with stronger SOC. All these psychological traits were influenced by genetic factors with heritability estimates ranging from 19 to 66%. Genetic and environmental factors explained these associations, but the genetic correlations were generally stronger. The PGS of major depressive disorder was associated with weaker, and the PGS of general risk tolerance with stronger SOC in men, whereas in women the PGS of subjective well-being was associated with stronger SOC and the PGSs of depression and neuroticism with weaker SOC. Conclusion Our results indicate that a substantial proportion of genetic variation in SOC is shared with mental health, self-esteem and personality indicators. This suggests that the correlations between these traits reflect a common neurobiological background rather than merely the influence of external stressors. en
dc.language.iso eng
dc.relation.ispartof Social Psychiatry and Psychiatric Epidemiology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Sense of coherence
dc.subject Mental health
dc.subject Personality
dc.subject Twins
dc.subject Polygenic score
dc.subject ANTONOVSKYS SENSE
dc.subject ENVIRONMENTAL-FACTORS
dc.subject DEPRESSIVE SYMPTOMS
dc.subject SCALE
dc.subject TWIN
dc.subject HERITABILITY
dc.subject ALEXITHYMIA
dc.subject CHILDHOOD
dc.subject ADULTHOOD
dc.subject LIFE
dc.subject 3142 Public health care science, environmental and occupational health
dc.title The genetic background of the associations between sense of coherence and mental health, self-esteem and personality en
dc.type Article
dc.contributor.organization Helsinki Inequality Initiative (INEQ)
dc.contributor.organization Doctoral Programme in Social Sciences
dc.contributor.organization Demography
dc.contributor.organization Doctoral Programme in Population Health
dc.contributor.organization Population Research Unit (PRU)
dc.contributor.organization Center for Population, Health and Society
dc.contributor.organization Sociology
dc.contributor.organization Cognitive and Brain Aging
dc.contributor.organization Doctoral Programme Brain & Mind
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization Genetic Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00127-021-02098-6
dc.relation.issn 0933-7954
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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