A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis

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Ouni , E , Peaucelle , A , Haas , K T , Van Kerk , O , Dolmans , M-M , Tuuri , T , Otala , M & Amorim , C A 2021 , ' A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis ' , Nature Communications , vol. 12 , no. 1 , 5603 . https://doi.org/10.1038/s41467-021-25934-4

Title: A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis
Author: Ouni, Emna; Peaucelle, Alexis; Haas, Kalina T.; Van Kerk, Olivier; Dolmans, Marie-Madeleine; Tuuri, Timo; Otala, Marjut; Amorim, Christiani A.
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Obstetrics and Gynecology
Date: 2021-09-23
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/336596
Abstract: Although the first dissection of the human ovary dates back to the 17th century, its characterization is still limited. Here, the authors have unraveled a unique biophysical and topological phenotype of reproductive-age tissue, bridging biophysics and female fertility and providing a blueprint for the artificial ovary. Although the first dissection of the human ovary dates back to the 17(th) century, the biophysical characteristics of the ovarian cell microenvironment are still poorly understood. However, this information is vital to deciphering cellular processes such as proliferation, morphology and differentiation, as well as pathologies like tumor progression, as demonstrated in other biological tissues. Here, we provide the first readout of human ovarian fiber morphology, interstitial and perifollicular fiber orientation, pore geometry, topography and surface roughness, and elastic and viscoelastic properties. By determining differences between healthy prepubertal, reproductive-age, and menopausal ovarian tissue, we unravel and elucidate a unique biophysical phenotype of reproductive-age tissue, bridging biophysics and female fertility. While these data enable to design of more biomimetic scaffolds for the tissue-engineered ovary, our analysis pipeline is applicable for the characterization of other organs in physiological or pathological states to reveal their biophysical markers or design their bioinspired analogs.
Subject: HIPPO SIGNALING DISRUPTION
EXTRACELLULAR-MATRIX
TISSUE
ARCHITECTURE
TOPOGRAPHY
COLLAGEN
FOLLICLES
GROWTH
BIOMATERIAL
ELASTICITY
3111 Biomedicine
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