CMC is more than a measure of corticospinal tract integrity in acute stroke patients

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dc.contributor.author Aikio, R.
dc.contributor.author Laaksonen, K.
dc.contributor.author Sairanen, A
dc.contributor.author Parkkonen, E.
dc.contributor.author Abou Elseoud, A.
dc.contributor.author Kujala, J.
dc.contributor.author Forss, N.
dc.date.accessioned 2021-11-24T10:38:05Z
dc.date.available 2021-11-24T10:38:05Z
dc.date.issued 2021
dc.identifier.citation Aikio , R , Laaksonen , K , Sairanen , A , Parkkonen , E , Abou Elseoud , A , Kujala , J & Forss , N 2021 , ' CMC is more than a measure of corticospinal tract integrity in acute stroke patients ' , NeuroImage: Clinical , vol. 32 , 102818 . https://doi.org/10.1016/j.nicl.2021.102818
dc.identifier.other PURE: 170581853
dc.identifier.other PURE UUID: 2e80cd32-a3ea-4329-a638-c7761bcb213a
dc.identifier.other WOS: 000702832800006
dc.identifier.other ORCID: /0000-0002-8833-7155/work/103727205
dc.identifier.other ORCID: /0000-0002-1620-8573/work/103727292
dc.identifier.uri http://hdl.handle.net/10138/336698
dc.description.abstract In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magneto encephalographic oscillatory signals were recorded from 29 patients with paresis of the upper extremity due to ischemic stroke and 22 control subjects. CMC amplitudes and peak frequencies at 13-30 Hz were compared between the two groups. In the patients, the peak frequency in both the affected and the unaffected hemisphere was significantly (p < 0.01) lower and the strength of CMC was significantly (p < 0.05) weaker in the affected hemisphere compared to the control subjects. The strength of CMC in the patients correlated with the level of tactile sensitivity and clinical test results of hand function. In contrast, no correlation between measures of CST integrity and CMC was found. The results confirm the earlier findings that CMC is altered in acute stroke and demonstrate that CMC is bidirectional and not solely a measure of integrity of the efferent corticospinal tract. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof NeuroImage: Clinical
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Afferent input
dc.subject Corticomuscular coherence
dc.subject Corticospinal tract integrity
dc.subject Magnetoencephalography
dc.subject Motor cortex
dc.subject Stroke
dc.subject MOTOR-CORTICAL OSCILLATIONS
dc.subject CORTICOMUSCULAR COHERENCE
dc.subject CORTEX EXCITABILITY
dc.subject DIFFUSION TENSOR
dc.subject EEG-EMG
dc.subject MUSCLE
dc.subject SYNCHRONIZATION
dc.subject CONTRACTION
dc.subject REORGANIZATION
dc.subject PRECISION
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title CMC is more than a measure of corticospinal tract integrity in acute stroke patients en
dc.type Article
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization HUS Neurocenter
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization Children's Hospital
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.nicl.2021.102818
dc.relation.issn 2213-1582
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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