Brain predictive coding processes are associated to COMT gene Val158Met polymorphism

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Bonetti , L , Bruzzone , SEP , Sedghi , NA , Haumann , NT , Paunio , T , Kantojarvi , K , Kliuchko , M , Vuust , P & Brattico , E 2021 , ' Brain predictive coding processes are associated to COMT gene Val158Met polymorphism ' , NeuroImage , vol. 233 , 117954 . https://doi.org/10.1016/j.neuroimage.2021.117954

Title: Brain predictive coding processes are associated to COMT gene Val158Met polymorphism
Author: Bonetti, L; Bruzzone, SEP; Sedghi, NA; Haumann, NT; Paunio, T; Kantojarvi, K; Kliuchko, M; Vuust, P; Brattico, E
Contributor organization: HUS Psychiatry
Department of Psychiatry
Clinicum
Date: 2021-06
Language: eng
Number of pages: 11
Belongs to series: NeuroImage
ISSN: 1053-8119
DOI: https://doi.org/10.1016/j.neuroimage.2021.117954
URI: http://hdl.handle.net/10138/336733
Abstract: Predicting events in the ever-changing environment is a fundamental survival function intrinsic to the physiology of sensory systems, whose efficiency varies among the population. Even though it is established that a major source of such variations is genetic heritage, there are no studies tracking down auditory predicting processes to genetic mutations. Thus, we examined the neurophysiological responses to deviant stimuli recorded with magnetoencephalography (MEG) in 108 healthy participants carrying different variants of Val158Met single-nucleotide polymorphism (SNP) within the catechol-O-methyltransferase (COMT) gene, responsible for the majority of catecholamines degradation in the prefrontal cortex. Our results showed significant amplitude enhancement of prediction error responses originating from the inferior frontal gyrus, superior and middle temporal cortices in heterozygous genotype carriers (Val/Met) vs homozygous (Val/Val and Met/Met) carriers. Integrating neurophysiology and genetics, this study shows how the neural mechanisms underlying optimal deviant detection vary according to the gene-determined cathecolamine levels in the brain.
Subject: Predictive coding
Mismatch negativity (MMN)
Catechol-O-methyltransferase (COMT) gene
Magnetoencephalography (MEG)
CATECHOL-O-METHYLTRANSFERASE
MISMATCH NEGATIVITY MMN
PREFRONTAL CORTEX
VAL(158)MET GENOTYPE
DOPAMINE TRANSPORTER
PARKINSONS-DISEASE
COGNITIVE FUNCTION
ENZYME-ACTIVITY
SENSORY MEMORY
MESSENGER-RNA
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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