Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

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http://hdl.handle.net/10138/336897

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Duong , TT , Isomaki , A , Paaver , U , Laidmae , I , Tonisoo , A , Yen , TTH , Kogermann , K , Raal , A , Heinamaki , J & Pham , TMH 2021 , ' Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes ' , Molecules , vol. 26 , no. 9 , 2591 . https://doi.org/10.3390/molecules26092591

Title: Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes
Author: Duong, TT; Isomaki, A; Paaver, U; Laidmae, I; Tonisoo, A; Yen, TTH; Kogermann, K; Raal, A; Heinamaki, J; Pham, TMH
Contributor organization: Department of Anatomy
Medicum
Date: 2021-05
Language: eng
Number of pages: 18
Belongs to series: Molecules
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules26092591
URI: http://hdl.handle.net/10138/336897
Abstract: Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.
Subject: berberine
poorly water-soluble alkaloid
liposomes
ethanol-injection
thin-film hydration
DRUG-DELIVERY
LIGHT-SCATTERING
BIOAVAILABILITY
NANOPARTICLES
TOCOPHEROL
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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