Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury

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Shaheryar , Z A , Khan , M A , Adnan , C S , Zaidi , A A , Hänggi , D & Muhammad , S 2021 , ' Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury ' , Frontiers in Immunology , vol. 12 , 748663 . https://doi.org/10.3389/fimmu.2021.748663

Title: Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
Author: Shaheryar, Zaib A.; Khan, Mahtab A.; Adnan, Ch. Sherjeel; Zaidi, Awais Ali; Hänggi, Daniel; Muhammad, Sajjad
Contributor organization: HUS Neurocenter
Clinicum
Neurokirurgian yksikkö
Date: 2021-10-07
Language: eng
Number of pages: 18
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2021.748663
URI: http://hdl.handle.net/10138/336967
Abstract: Ischemic stroke is one of the leading causes of morbidity and mortality globally. Hundreds of clinical trials have proven ineffective in bringing forth a definitive and effective treatment for ischemic stroke, except a myopic class of thrombolytic drugs. That, too, has little to do with treating long-term post-stroke disabilities. These studies proposed diverse options to treat stroke, ranging from neurotropic interpolation to venting antioxidant activity, from blocking specific receptors to obstructing functional capacity of ion channels, and more recently the utilization of neuroprotective substances. However, state of the art knowledge suggests that more pragmatic focus in finding effective therapeutic remedy for stroke might be targeting intricate intracellular signaling pathways of the 'neuroinflammatory triangle': ROS burst, inflammatory cytokines, and BBB disruption. Experimental evidence reviewed here supports the notion that allowing neuroprotective mechanisms to advance, while limiting neuroinflammatory cascades, will help confine post-stroke damage and disabilities.
Subject: neuroinflammation
blood brain barrier
cytokine
brain microvascular endothelial cell
reactive oxidative species
NF-KAPPA-B
NECROSIS-FACTOR-ALPHA
NITRIC-OXIDE SYNTHASE
CENTRAL-NERVOUS-SYSTEM
NEUROTROPHIC FACTOR EXPRESSION
OXIDATIVE STRESS
IFN-GAMMA
ENDOTHELIAL-CELLS
SIGNALING PATHWAY
GROWTH-FACTOR
3112 Neurosciences
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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