Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel

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Hasselmann , S , Hahn , L , Lorson , T , Schaetzlein , E , Sebastien , I , Beudert , M , Luehmann , T , Neubauer , J C , Sextl , G , Luxenhofer , R & Heinrich , D 2021 , ' Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel ' , Materials Horizons , vol. 8 , no. 12 , pp. 3334-3344 . https://doi.org/10.1039/d1mh00925g

Title: Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogel
Author: Hasselmann, Sebastian; Hahn, Lukas; Lorson, Thomas; Schaetzlein, Eva; Sebastien, Isabelle; Beudert, Matthias; Luehmann, Tessa; Neubauer, Julia C.; Sextl, Gerhard; Luxenhofer, Robert; Heinrich, Doris
Contributor organization: Helsinki Institute of Sustainability Science (HELSUS)
Polymers
Department of Chemistry
Date: 2021-11-29
Language: eng
Number of pages: 11
Belongs to series: Materials Horizons
ISSN: 2051-6347
DOI: https://doi.org/10.1039/d1mh00925g
URI: http://hdl.handle.net/10138/337061
Abstract: In this study, a novel approach to create arbitrarily shaped 3D hydrogel objects is presented, wherein freeform two-photon polymerization (2PP) is enabled by the combination of a photosensitive hydrogel and an intrinsic support matrix. This way, topologies without physical contact such as a highly porous 3D network of concatenated rings were realized, which are impossible to manufacture with most current 3D printing technologies. Micro-Raman and nanoindentation measurements show the possibility to control water uptake and hence tailor the Young's modulus of the structures via the light dosage, proving the versatility of the concept regarding many scaffold characteristics that makes it well suited for cell specific cell culture as demonstrated by cultivation of human induced pluripotent stem cell derived cardiomyocytes.
Subject: CELL-MIGRATION
2-PHOTON POLYMERIZATION
FABRICATION
ADHESION
DIFFERENTIATION
FIBROBLASTS
TECHNOLOGY
DELIVERY
FORCES
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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