An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases

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Chan , Y , Lim , E T , Sandholm , N , Wang , S R , McKnight , A J , Ripke , S , Daly , M J , Neale , B M , Salem , R M , Hirschhorn , J N , DIAGRAM Consortium , GENIE Consortium , GIANT Consortium , IIBDGC Consortium & PGC Consortium 2014 , ' An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases ' , American Journal of Human Genetics , vol. 94 , no. 3 , pp. 437-452 . https://doi.org/10.1016/j.ajhg.2014.02.006

Titel: An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases
Författare: Chan, Yingleong; Lim, Elaine T.; Sandholm, Niina; Wang, Sophie R.; McKnight, Amy Jayne; Ripke, Stephan; Daly, Mark J.; Neale, Benjamin M.; Salem, Rany M.; Hirschhorn, Joel N.; DIAGRAM Consortium; GENIE Consortium; GIANT Consortium; IIBDGC Consortium; PGC Consortium
Upphovmannens organisation: Clinicum
Department of Medicine
Nefrologian yksikkö
Datum: 2014-03-06
Språk: eng
Sidantal: 16
Tillhör serie: American Journal of Human Genetics
ISSN: 0002-9297
DOI: https://doi.org/10.1016/j.ajhg.2014.02.006
Permanenta länken (URI): http://hdl.handle.net/10138/337093
Subject: GENOME-WIDE ASSOCIATION
INFLAMMATORY-BOWEL-DISEASE
GENETIC ARCHITECTURE
MISSING HERITABILITY
ULCERATIVE-COLITIS
PROVIDES INSIGHTS
COMMON SNPS
METAANALYSIS
LOCI
SUSCEPTIBILITY
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: other
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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