An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases

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dc.contributor.author Chan, Yingleong
dc.contributor.author Lim, Elaine T.
dc.contributor.author Sandholm, Niina
dc.contributor.author Wang, Sophie R.
dc.contributor.author McKnight, Amy Jayne
dc.contributor.author Ripke, Stephan
dc.contributor.author Daly, Mark J.
dc.contributor.author Neale, Benjamin M.
dc.contributor.author Salem, Rany M.
dc.contributor.author Hirschhorn, Joel N.
dc.contributor.author DIAGRAM Consortium
dc.contributor.author GENIE Consortium
dc.contributor.author GIANT Consortium
dc.contributor.author IIBDGC Consortium
dc.contributor.author PGC Consortium
dc.date.accessioned 2021-12-03T14:13:01Z
dc.date.available 2021-12-03T14:13:01Z
dc.date.issued 2014-03-06
dc.identifier.citation Chan , Y , Lim , E T , Sandholm , N , Wang , S R , McKnight , A J , Ripke , S , Daly , M J , Neale , B M , Salem , R M , Hirschhorn , J N , DIAGRAM Consortium , GENIE Consortium , GIANT Consortium , IIBDGC Consortium & PGC Consortium 2014 , ' An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases ' , American Journal of Human Genetics , vol. 94 , no. 3 , pp. 437-452 . https://doi.org/10.1016/j.ajhg.2014.02.006
dc.identifier.other PURE: 38269071
dc.identifier.other PURE UUID: e10271bf-9214-4532-abd4-e3aa14e3b23d
dc.identifier.other WOS: 000332611400017
dc.identifier.other Scopus: 84896780157
dc.identifier.other ORCID: /0000-0003-4322-6942/work/44577643
dc.identifier.uri http://hdl.handle.net/10138/337093
dc.format.extent 16
dc.language.iso eng
dc.relation.ispartof American Journal of Human Genetics
dc.rights other
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GENOME-WIDE ASSOCIATION
dc.subject INFLAMMATORY-BOWEL-DISEASE
dc.subject GENETIC ARCHITECTURE
dc.subject MISSING HERITABILITY
dc.subject ULCERATIVE-COLITIS
dc.subject PROVIDES INSIGHTS
dc.subject COMMON SNPS
dc.subject METAANALYSIS
dc.subject LOCI
dc.subject SUSCEPTIBILITY
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Medicine
dc.contributor.organization Nefrologian yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ajhg.2014.02.006
dc.relation.issn 0002-9297
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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