Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

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Lin , W Y , Fordham , S E , Hungate , E , Sunter , N J , Elstob , C , Xu , Y , Park , C , Quante , A , Strauch , K , Gieger , C , Skol , A , Rahman , T , Sucheston-Campbell , L , Wang , J , Hahn , T , Clay-Gilmour , A I , Jones , G L , Marr , H J , Jackson , G H , Menne , T , Collin , M , Ivey , A , Hills , R K , Burnett , A K , Russell , N H , Fitzgibbon , J , Larson , R A , Le Beau , M M , Stock , W , Heidenreich , O , Alharbi , A , Allsup , D J , Houlston , R S , Norden , J , Dickinson , A M , Douglas , E , Lendrem , C , Daly , A K , Palm , L , Piechocki , K , Jeffries , S , Bornhäuser , M , Röllig , C , Altmann , H , Ruhnke , L , Kunadt , D , Wagenführ , L , Cordell , H J , Darlay , R , Andersen , M K , Fontana , M C , Martinelli , G , Marconi , G , Sanz , M A , Cervera , J , Gómez-Seguí , I , Cluzeau , T , Moreilhon , C , Raynaud , S , Sill , H , Voso , M T , Lo-Coco , F , Dombret , H , Cheok , M , Preudhomme , C , Gale , R E , Linch , D , Gaal-Wesinger , J , Masszi , A , Nowak , D , Hofmann , W K , Gilkes , A , Porkka , K , Milosevic Feenstra , J D , Kralovics , R , Grimwade , D , Meggendorfer , M , Haferlach , T , Krizsán , S , Bödör , C , Stölzel , F , Onel , K & Allan , J M 2021 , ' Genome-wide association study identifies susceptibility loci for acute myeloid leukemia ' , Nature Communications , vol. 12 , no. 1 , 6233 . https://doi.org/10.1038/s41467-021-26551-x

Title: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Author: Lin, Wei Yu; Fordham, Sarah E.; Hungate, Eric; Sunter, Nicola J.; Elstob, Claire; Xu, Yaobo; Park, Catherine; Quante, Anne; Strauch, Konstantin; Gieger, Christian; Skol, Andrew; Rahman, Thahira; Sucheston-Campbell, Lara; Wang, Junke; Hahn, Theresa; Clay-Gilmour, Alyssa I.; Jones, Gail L.; Marr, Helen J.; Jackson, Graham H.; Menne, Tobias; Collin, Mathew; Ivey, Adam; Hills, Robert K.; Burnett, Alan K.; Russell, Nigel H.; Fitzgibbon, Jude; Larson, Richard A.; Le Beau, Michelle M.; Stock, Wendy; Heidenreich, Olaf; Alharbi, Abrar; Allsup, David J.; Houlston, Richard S.; Norden, Jean; Dickinson, Anne M.; Douglas, Elisabeth; Lendrem, Clare; Daly, Ann K.; Palm, Louise; Piechocki, Kim; Jeffries, Sally; Bornhäuser, Martin; Röllig, Christoph; Altmann, Heidi; Ruhnke, Leo; Kunadt, Desiree; Wagenführ, Lisa; Cordell, Heather J.; Darlay, Rebecca; Andersen, Mette K.; Fontana, Maria C.; Martinelli, Giovanni; Marconi, Giovani; Sanz, Miguel A.; Cervera, José; Gómez-Seguí, Inés; Cluzeau, Thomas; Moreilhon, Chimène; Raynaud, Sophie; Sill, Heinz; Voso, Maria Teresa; Lo-Coco, Francesco; Dombret, Hervé; Cheok, Meyling; Preudhomme, Claude; Gale, Rosemary E.; Linch, David; Gaal-Wesinger, Julia; Masszi, Andras; Nowak, Daniel; Hofmann, Wolf Karsten; Gilkes, Amanda; Porkka, Kimmo; Milosevic Feenstra, Jelena D.; Kralovics, Robert; Grimwade, David; Meggendorfer, Manja; Haferlach, Torsten; Krizsán, Szilvia; Bödör, Csaba; Stölzel, Friedrich; Onel, Kenan; Allan, James M.
Contributor organization: HUS Comprehensive Cancer Center
University Management
Helsinki University Hospital Area
Department of Oncology
Hematologian yksikkö
Date: 2021-10-29
Language: eng
Number of pages: 10
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-021-26551-x
URI: http://hdl.handle.net/10138/337099
Abstract: Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 x 10(-8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 x 10(-10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.
Description: Publisher Copyright: © 2021, The Author(s).
Subject: 3111 Biomedicine
HUMAN-LEUKOCYTE ANTIGEN
IMMUNE ESCAPE
CLONAL EVOLUTION
GENE-MUTATIONS
OLDER PATIENTS
RISK
CANCER
HLA
HIF-1-ALPHA
AML
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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