The skin microbiome : investigations on skin malignancies and preterm newborn skin

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http://hdl.handle.net/10138/337122

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Salava , A 2018 , ' The skin microbiome : investigations on skin malignancies and preterm newborn skin ' , University of Helsinki , Helsinki . < https://helda.helsinki.fi/bitstream/handle/10138/232567/THESKINM.pdf?sequence=1&isAllowed=y >

Title: The skin microbiome : investigations on skin malignancies and preterm newborn skin
Author: Salava, Alexander
Other contributor: Lauerma, Antti
Contributor organization: Department of Dermatology, Allergology and Venereology
HUS Inflammation Center
Publisher: [A. Salava]
Date: 2018-04-06
Language: eng
Number of pages: 64
ISBN: 978-951-51-3156-0
978-951-51-3157-7
URI: http://hdl.handle.net/10138/337122
Abstract: The skin microbiome – Investigations on skin malignancies and preterm newborn skin Skin disorders have been associated with specific microbiome changes and raised an interest in developing new diagnostic methods and treatments. Our object was to investigate the microbiome in skin cancer (melanoma) and inflammatory skin disorders (parapsoriasis) and to explore the skin microbiome in very low birth weight infants in intensive care and possible association to neonatal sepsis. Microbiome samples were taken of 15 cutaneous melanomas and 17 benign melanocytic nevi, of 13 patients with parapsoriasis and 12 very low birth weight infants during treatment in intensive care. Sequencing was carried out on 454 GS-FLX Titanium and Illumina MiSeq platforms and the data was analyzed by bioinformatics. There were no significant differences in the microbiome of melanomas, melanocytic nevi and controls. Additionally, the microbiome showed no significant differences between parapsoriasis and the same patient’s healthy skin. We observed a high cutaneous microbial diversity in most of the infants at birth and there was a decrease in diversity during the first three weeks of life. There was no association between microbiome changes and neonatal sepsis. The results suggest that microbiome swab sampling may not be helpful in diagnostics of melanoma or parapsoriasis. Moreover, microbiome changes seem not to play a role in parapsoriasis. We could demonstrate that very low birth weight infants in intensive care have a high cutaneous microbial diversity during the first days of life regardless of the way of delivery, prematurity causes or perinatal infections. The diversity decreases during the first weeks of life possibly due to intensive care treatment and antibiotics. Neonatal sepsis is not linked to microbiome changes and it is likely that other factors play a role, e.g. skin injury by medical devices and concomitant infections.
Description: M1 - 64 s. + liitteet
Subject: Infant, Premature
Skin
+microbiology
Microbiota
Melanoma
Parapsoriasis
Nevus, Pigmented
Skin Neoplasms
Infant, Very Low Birth Weight
Infant, Low Birth Weight
Neonatal Sepsis
Enterotoxins
Lymphoma, T-Cell
Mycosis Fungoides
Staphylococcal Infections
Staphylococcus aureus
Intensive Care, Neonatal
3121 General medicine, internal medicine and other clinical medicine
Usage restriction: openAccess
Self-archived version: publishedVersion


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