The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network`

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Selenius , J S , Silveira , P P , Salonen , M , Kautiainen , H , von Bonsdorff , M , Kajantie , E , Lahti , J , Eriksson , J G & Wasenius , N S 2021 , ' The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network` ' , Scientific Reports , vol. 11 , no. 1 , 21588 . https://doi.org/10.1038/s41598-021-00631-w

Title: The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network`
Author: Selenius, Jannica S.; Silveira, Patricia P.; Salonen, Minna; Kautiainen, Hannu; von Bonsdorff, Mikaela; Kajantie, Eero; Lahti, Jari; Eriksson, Johan G.; Wasenius, Niko S.
Contributor organization: Department of General Practice and Primary Health Care
Helsinki University Hospital Area
Clinicum
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
University of Helsinki
Department of Psychology and Logopedics
Research Programs Unit
Johan Eriksson / Principal Investigator
Date: 2021-11-03
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-00631-w
URI: http://hdl.handle.net/10138/337228
Abstract: To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7-7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = - 3.4, 95% CI -5.6 to - 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.
Subject: METABOLIC SYNDROME
PSYCHOMETRIC PROPERTIES
INVENTORY-II
METAANALYSIS
ASSOCIATION
PREVALENCE
RESISTANCE
DISORDER
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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