Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden

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http://hdl.handle.net/10138/337230

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Hemminki , K , Försti , A , Chen , T & Hemminki , A 2021 , ' Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden ' , BMC Cancer , vol. 21 , no. 1 , 1189 . https://doi.org/10.1186/s12885-021-08913-2

Title: Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
Author: Hemminki, Kari; Försti, Asta; Chen, Tianhui; Hemminki, Akseli
Contributor organization: Department of Oncology
HUS Comprehensive Cancer Center
University of Helsinki
TRIMM - Translational Immunology Research Program
Date: 2021-11-08
Language: eng
Number of pages: 8
Belongs to series: BMC Cancer
ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08913-2
URI: http://hdl.handle.net/10138/337230
Abstract: Background: Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence trends for MPM remain poorly characterized. We use nationwide MPM data for Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) to assess incidence, mortality and survival trends for MPM in these countries. Methods: We use the NORDCAN database for the analyses: incidence data were available from 1943 in DK, 1953 in FI and NO and 1958 in SE, through 2016. Survival data were available from 1967 through 2016. World standard population was used in age standardization. Results: The lowest incidence that we recorded for MPM was 0.02/100,000 for NO women and 0.05/100,000 for FI men in 1953–57, marking the incidence before the influence of asbestos. The highest rate of 1.9/100,000 was recorded for DK in 1997. Female incidence was much lower than male incidence. In each country, the male incidence trend for MPM culminated, first in SE around 1990. The regional incidence trends matched with earlier asbestos-related industrial activity, shipbuilding in FI and SE, cement manufacturing and shipbuilding in DK and seafaring in NO. Relative 1-year survival increased from about 20 to 50% but 5-year survival remained at or below 10%. Conclusion: In the Nordic countries, the male incidence trends for MPM climaxed and started to decrease, indicating that the prevention of exposure was beneficial. Survival in MPM has improved for both sexes but long-term survival remains dismal.
Description: Publisher Copyright: © 2021, The Author(s).
Subject: 3122 Cancers
Age-specific incidence
Birth cohort analysis
Incidence trends
Regional incidence
Relative survival
Risk factors
CANCER REGISTRIES
SURVEILLANCE
END
TRENDS
EPIDEMIOLOGY
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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