Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders

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Kivelä , J , Sormunen-Harju , H , Girchenko , P , Huvinen , E , Stach-Lempinen , B , Kajantie , E , Villa , P M , Reynolds , R M , Hämäläinen , E K , Lahti-Pulkkinen , M , Murtoniemi , K K , Laivuori , H , Eriksson , J G , Räikkönen , K & Koivusalo , S B 2021 , ' Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders ' , Journal of Clinical Endocrinology and Metabolism , vol. 106 , no. 11 , pp. E4372-E4388 . https://doi.org/10.1210/clinem/dgab475

Title: Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders
Author: Kivelä, Jemina; Sormunen-Harju, Heidi; Girchenko, Polina; Huvinen, Emilia; Stach-Lempinen, Beata; Kajantie, Eero; Villa, Pia M.; Reynolds, Rebecca M.; Hämäläinen, Esa K.; Lahti-Pulkkinen, Marius; Murtoniemi, Katja K.; Laivuori, Hannele; Eriksson, Johan G.; Räikkönen, Katri; Koivusalo, Saila B.
Contributor organization: Department of Public Health
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Department of Psychology and Logopedics
Developmental Psychology Research Group
HYKS erva
South Carelia Social and Health care District Eksote
HUS Children and Adolescents
Lastentautien yksikkö
Children's Hospital
Clinicum
University of Helsinki
Hyvinkää Hospital Area
HUSLAB
Medicum
Department of Medical and Clinical Genetics
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
Pregnancy and Genes
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Doctoral Programme in Human Behaviour
Date: 2021-11
Language: eng
Number of pages: 17
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
DOI: https://doi.org/10.1210/clinem/dgab475
URI: http://hdl.handle.net/10138/337335
Abstract: Context: Comprehensive assessment of metabolism in maternal obesity and pregnancy disorders can provide information about the shared maternal-fetal milieu and give insight into both maternal long-term health and intergenerational transmission of disease burden. Objective: To assess levels, profiles, and change in the levels of metabolic measures during pregnancies complicated by obesity, gestational diabetes (GDM), or hypertensive disorders. Design, Setting and Participants: A secondary analysis of 2 study cohorts, PREDO and RADIEL, including 741 pregnant women. Main Outcome Measures: We assessed 225 metabolic measures by nuclear magnetic resonance in blood samples collected at median 13 [interquartile range (IQR) 12.4-13.7], 20 (IQR 19.3-23.0), and 28 (27.0-35.0) weeks of gestation. Results: Across all 3 time points women with obesity [body mass index (BMI) >= 30 kg/m(2)] in comparison to normal weight (BMI 18.5-24.99 kg/m(2)) had significantly higher levels of most very-low-density lipoprotein-related measures, many fatty and most amino acids, and more adverse metabolic profiles. The change in the levels of most metabolic measures during pregnancy was smaller in obese than in normal weight women. GDM, preeclampsia, and chronic hypertension were associated with metabolic alterations similar to obesity. The associations of obesity held after adjustment for GDM and hypertensive disorders, but many of the associations with GDM and hypertensive disorders were rendered nonsignificant after adjustment for BMI and the other pregnancy disorders. Conclusions: This study shows that the pregnancy-related metabolic change is smaller in women with obesity, who display metabolic perturbations already in early pregnancy. Metabolic alterations of obesity and pregnancy disorders resembled each other suggesting a shared metabolic origin.
Subject: diabetes
gestational
hypertension
metabolomics
nuclear magnetic resonance
biomolecular
pre-eclampsia
pregnancy
pregnant women
HEALTH
WOMEN
ACID
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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