Neuropathological evidence of body-first vs. brain-first Lewy body disease

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Borghammer , P , Horsager , J , Andersen , K , Van den Berge , N , Raunio , A , Murayama , S , Parkkinen , L & Myllykangas , L 2021 , ' Neuropathological evidence of body-first vs. brain-first Lewy body disease ' , Neurobiology of Disease , vol. 161 , 105557 . https://doi.org/10.1016/j.nbd.2021.105557

Title: Neuropathological evidence of body-first vs. brain-first Lewy body disease
Author: Borghammer, Per; Horsager, Jacob; Andersen, Katrine; Van den Berge, Nathalie; Raunio, Anna; Murayama, Shigeo; Parkkinen, Laura; Myllykangas, Liisa
Contributor organization: HUSLAB
Department of Pathology
HUS Diagnostic Center
Date: 2021-12
Language: eng
Number of pages: 10
Belongs to series: Neurobiology of Disease
ISSN: 0969-9961
DOI: https://doi.org/10.1016/j.nbd.2021.105557
URI: http://hdl.handle.net/10138/337640
Abstract: Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most abundant pathology in the "center of the brain", including the amygdala, entorhinal cortex, and substantia nigra, and relatively less pathology in the lower brainstem and spinal autonomic nuclei. The recent body-first versus brain-first model of Lewy Body Disorders proposes that the initial pathogenic alpha-synuclein in some patients originates in the enteric nervous system with secondary spreading to the brain; and in other patients originates inside the CNS with secondary spreading to the lower brainstem and peripheral autonomic nervous system. Here, we use two existing post mortem datasets to explore the possibility that clinical body-first and brain-first subtypes are equivalent to the caudo-rostral and amygdala-centered patterns of Lewy pathology seen at post mortem.
Subject: Lewy body
Parkinson's disease
Alpha-synuclein
Dementia with Lewy bodies
PATHOLOGICAL ALPHA-SYNUCLEIN
SLEEP BEHAVIOR DISORDER
ENTERIC NERVOUS-SYSTEM
PARKINSONS-DISEASE
GASTROINTESTINAL-TRACT
BODIES
SPREAD
PROPAGATION
PRIONS
GUT
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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