Serotonergic Antidepressants and Risk for Traumatic Intracranial Bleeding

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Isokuortti , H , Iverson , G L , Posti , J P , Ruuskanen , J O , Brander , A , Kataja , A , Nikula , M , Öhman , J & Luoto , T M 2021 , ' Serotonergic Antidepressants and Risk for Traumatic Intracranial Bleeding ' , Frontiers in neurology , vol. 12 , 758707 . https://doi.org/10.3389/fneur.2021.758707

Title: Serotonergic Antidepressants and Risk for Traumatic Intracranial Bleeding
Author: Isokuortti, Harri; Iverson, Grant L.; Posti, Jussi P.; Ruuskanen, Jori O.; Brander, Antti; Kataja, Anneli; Nikula, Milaja; Öhman, Juha; Luoto, Teemu M.
Contributor organization: HUS Neurocenter
University of Helsinki
Neurokirurgian yksikkö
Date: 2021-10-28
Language: eng
Number of pages: 8
Belongs to series: Frontiers in neurology
ISSN: 1664-2295
DOI: https://doi.org/10.3389/fneur.2021.758707
URI: http://hdl.handle.net/10138/337648
Abstract: Background: Serotonergic antidepressants may predispose to bleeding but the effect on traumatic intracranial bleeding is unknown.Methods: The rate of intracranial bleeding in patients with antidepressant medication was compared to patients not antidepressants in a cohort of patients with acute head injury. This association was examined by using a consecutive cohort of head trauma patients from a Finnish tertiary center emergency department (Tampere University Hospital, Tampere, Finland). All consecutive (2010-2012) adult patients (n = 2,890; median age = 58; male = 56%, CT-positive = 22%, antithrombotic medication users = 25%, antidepressant users = 10%) who underwent head CT due to head trauma in the emergency department were included.Results: Male gender, GCS
Subject: brain injuries
traumatic
intracranial hemorrhages
antidepressant agents
anticoagulation
antithrombotic agents (MeSH)
REUPTAKE INHIBITORS
PLATELET-FUNCTION
COMPUTED-TOMOGRAPHY
BRAIN-INJURY
HEAD-INJURY
MILD
ASSOCIATION
HEMORRHAGE
GUIDELINES
MORTALITY
3112 Neurosciences
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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