Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome

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Depommier , C , Everard , A , Druart , C , Maiter , D , Thissen , J-P , Loumaye , A , Hermans , M P , Delzenne , N M , de Vos , W M & Cani , P D 2021 , ' Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome ' , Gut Microbes , vol. 13 , no. 1 , 1994270 . https://doi.org/10.1080/19490976.2021.1994270

Title: Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
Author: Depommier, Clara; Everard, Amandine; Druart, Celine; Maiter, Dominique; Thissen, Jean-Paul; Loumaye, Audrey; Hermans, Michel P.; Delzenne, Nathalie M.; de Vos, Willem M.; Cani, Patrice D.
Contributor organization: Department of Bacteriology and Immunology
Willem Meindert Vos de / Principal Investigator
de Vos & Salonen group
Research Programs Unit
Departments of Faculty of Veterinary Medicine
HUMI - Human Microbiome Research
Date: 2021-01-01
Language: eng
Number of pages: 19
Belongs to series: Gut Microbes
ISSN: 1949-0976
DOI: https://doi.org/10.1080/19490976.2021.1994270
URI: http://hdl.handle.net/10138/337653
Abstract: Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at identifying metabolic signatures associated with beneficial properties of alive and pasteurized A. muciniphila when administrated to a cohort of insulin-resistant individuals with metabolic syndrome. Our data highlighted either shared or specific alterations in the metabolome according to the form of A. muciniphila administered with respect to a control group. Common responses encompassed modulation of amino acid metabolism, characterized by reduced levels of arginine and alanine, alongside several intermediates of tyrosine, phenylalanine, tryptophan, and glutathione metabolism. The global increase in levels of acylcarnitines together with specific modulation of acetoacetate also suggested induction of ketogenesis through enhanced beta-oxidation. Moreover, our data pinpointed some metabolites of interest considering their emergence as substantial compounds pertaining to health and diseases in the more recent literature.
Subject: A
muciniphila
human
obesity
metabolic syndrome
prediabetes
metabolomic
amino-acids
ketone bodies
acylcarnitines
HUMAN GUT MICROBIOME
AKKERMANSIA-MUCINIPHILA
INSULIN-RESISTANCE
ACID-METABOLISM
KETOGENIC DIET
OBESITY
OVERWEIGHT
CONTRIBUTE
RISK
3121 General medicine, internal medicine and other clinical medicine
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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