Genital Tract GAS Infection ISIDOG Guidelines

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Donders , G , Greenhouse , P , Donders , F , Engel , U , Paavonen , J & Mendling , W 2021 , ' Genital Tract GAS Infection ISIDOG Guidelines ' , Journal of clinical medicine , vol. 10 , no. 9 , 2043 . https://doi.org/10.3390/jcm10092043

Title: Genital Tract GAS Infection ISIDOG Guidelines
Author: Donders, G; Greenhouse, P; Donders, F; Engel, U; Paavonen, J; Mendling, W
Contributor organization: HUS Gynecology and Obstetrics
Clinicum
Department of Obstetrics and Gynecology
Date: 2021-05
Language: eng
Number of pages: 24
Belongs to series: Journal of clinical medicine
ISSN: 2077-0383
DOI: https://doi.org/10.3390/jcm10092043
URI: http://hdl.handle.net/10138/337778
Abstract: There has been an increasing worldwide incidence of invasive group A streptococcal (GAS) disease in pregnancy and in the puerperal period over the past 30 years. Postpartum Group A streptococci infection, and in particular streptococcal toxic shock syndrome (TSS) and necrotizing fasciitis, can be life threatening and difficult to treat. Despite antibiotics and supportive therapy, and in some cases advanced extensive surgery, mortality associated with invasive group A streptococcal postpartum endometritis, necrotizing fasciitis, and toxic shock syndrome remains high, up to 40% of postpartum septic deaths. It now accounts for more than 75,000 deaths worldwide every year. Postpartum women have a 20-fold increased incidence of GAS disease compared to non-pregnant women. Despite the high incidence, many invasive GAS infections are not diagnosed in a timely manner, resulting in potentially preventable maternal and neonatal deaths. In this paper the specific characteristics of GAS infection in the field of Ob/Gyn are brought to our attention, resulting in guidelines to improve our awareness, early recognition and timely treatment of the disease. New European prevalence data of vaginal GAS colonization are presented, alongside two original case histories. Additionally, aerobic vaginitis is proposed as a supplementary risk factor for invasive GAS diseases.
Subject: Streptococcus pyogenes
sepsis
puerperal infection
maternal mortality
invasive GAS infection
endometritis
GROUP-A STREPTOCOCCUS
FIBRONECTIN-BINDING PROTEIN
INTERNALIZATION-ASSOCIATED GENE
CHRONIC PHARYNGEAL CARRIAGE
GROUP-B STREPTOCOCCUS
TOXIC-SHOCK-SYNDROME
VULVO-VAGINITIS
CLINICAL-MANIFESTATIONS
ERYTHROMYCIN RESISTANCE
HEMOLYTIC STREPTOCOCCI
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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