Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction

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Pysyväisosoite

http://hdl.handle.net/10138/338088

Lähdeviite

Kerola , A M , Palomäki , A , Rautava , P , Nuotio , M & Kytö , V 2021 , ' Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction ' , Journal of the American Heart Association , vol. 10 , no. 23 , 022883 . https://doi.org/10.1161/JAHA.121.022883

Julkaisun nimi: Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction
Tekijä: Kerola, Anne M.; Palomäki, Antti; Rautava, Päivi; Nuotio, Maria; Kytö, Ville
Tekijän organisaatio: Faculty of Medicine
Päijät-Häme Welfare Consortium
Clinicum
Department of Public Health
Päiväys: 2021-12-07
Kieli: eng
Sivumäärä: 23
Kuuluu julkaisusarjaan: Journal of the American Heart Association
ISSN: 2047-9980
DOI-tunniste: https://doi.org/10.1161/JAHA.121.022883
URI: http://hdl.handle.net/10138/338088
Tiivistelmä: Background Evidence on the impact of sex on prognoses after myocardial infarction (MI) among older adults is limited. We evaluated sex differences in long-term cardiovascular outcomes after MI in older adults. Methods and Results All patients with MI >= 70 years admitted to 20 Finnish hospitals during a 10-year period and discharged alive were studied retrospectively using a combination of national registries (n=31 578, 51% men, mean age 79). The primary outcome was combined major adverse cardiovascular event within 10-year follow-up. Sex differences in baseline features were equalized using inverse probability weighting adjustment. Women were older, with different comorbidity profiles and rarer ST-segment-elevation MI and revascularization, compared with men. Adenosine diphosphate inhibitors, anticoagulation, statins, and high-dose statins were more frequently used by men, and renin-angiotensin-aldosterone inhibitors and beta blockers by women. After balancing these differences by inverse probability weighting, the cumulative 10-year incidence of major adverse cardiovascular events was 67.7% in men, 62.0% in women (hazard ratio [HR], 1.17; CI, 1.13-1.21; P= 80 years. Conclusions Older men had higher long-term risk of major adverse cardiovascular events after MI, compared with older women with similar baseline features and evidence-based medications. Our results highlight the importance of accounting for confounding factors when studying sex differences in cardiovascular outcomes.
Avainsanat: cohort study
coronary artery disease
gender differences
myocardial infarction
outcomes
LONG-TERM MORTALITY
ALL-CAUSE MORTALITY
CORONARY ATHEROSCLEROSIS
STATIN USE
GENDER
SURVIVAL
INSIGHTS
FRAILTY
DEATH
WOMEN
3121 General medicine, internal medicine and other clinical medicine
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by_nc
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


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