Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction

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dc.contributor.author Kerola, Anne M.
dc.contributor.author Palomäki, Antti
dc.contributor.author Rautava, Päivi
dc.contributor.author Nuotio, Maria
dc.contributor.author Kytö, Ville
dc.date.accessioned 2021-12-29T12:00:01Z
dc.date.available 2021-12-29T12:00:01Z
dc.date.issued 2021-12-07
dc.identifier.citation Kerola , A M , Palomäki , A , Rautava , P , Nuotio , M & Kytö , V 2021 , ' Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction ' , Journal of the American Heart Association , vol. 10 , no. 23 , 022883 . https://doi.org/10.1161/JAHA.121.022883
dc.identifier.other PURE: 171937990
dc.identifier.other PURE UUID: b08d6f0d-6fb4-4b84-94e1-d0d7f818736e
dc.identifier.other WOS: 000727412400011
dc.identifier.uri http://hdl.handle.net/10138/338088
dc.description.abstract Background Evidence on the impact of sex on prognoses after myocardial infarction (MI) among older adults is limited. We evaluated sex differences in long-term cardiovascular outcomes after MI in older adults. Methods and Results All patients with MI >= 70 years admitted to 20 Finnish hospitals during a 10-year period and discharged alive were studied retrospectively using a combination of national registries (n=31 578, 51% men, mean age 79). The primary outcome was combined major adverse cardiovascular event within 10-year follow-up. Sex differences in baseline features were equalized using inverse probability weighting adjustment. Women were older, with different comorbidity profiles and rarer ST-segment-elevation MI and revascularization, compared with men. Adenosine diphosphate inhibitors, anticoagulation, statins, and high-dose statins were more frequently used by men, and renin-angiotensin-aldosterone inhibitors and beta blockers by women. After balancing these differences by inverse probability weighting, the cumulative 10-year incidence of major adverse cardiovascular events was 67.7% in men, 62.0% in women (hazard ratio [HR], 1.17; CI, 1.13-1.21; P= 80 years. Conclusions Older men had higher long-term risk of major adverse cardiovascular events after MI, compared with older women with similar baseline features and evidence-based medications. Our results highlight the importance of accounting for confounding factors when studying sex differences in cardiovascular outcomes. en
dc.format.extent 23
dc.language.iso eng
dc.relation.ispartof Journal of the American Heart Association
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject cohort study
dc.subject coronary artery disease
dc.subject gender differences
dc.subject myocardial infarction
dc.subject outcomes
dc.subject LONG-TERM MORTALITY
dc.subject ALL-CAUSE MORTALITY
dc.subject CORONARY ATHEROSCLEROSIS
dc.subject STATIN USE
dc.subject GENDER
dc.subject SURVIVAL
dc.subject INSIGHTS
dc.subject FRAILTY
dc.subject DEATH
dc.subject WOMEN
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Sex Differences in Cardiovascular Outcomes of Older Adults After Myocardial Infarction en
dc.type Article
dc.contributor.organization Faculty of Medicine
dc.contributor.organization Päijät-Häme Welfare Consortium
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1161/JAHA.121.022883
dc.relation.issn 2047-9980
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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