Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease : Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts

Show full item record



Permalink

http://hdl.handle.net/10138/338095

Citation

Tikkanen , E , Jagerroos , V , Holmes , M , Sattar , N , Ala-Korpela , M , Jousilahti , P , Lundqvist , A , Perola , M , Salomaa , V & Wurtz , P 2021 , ' Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease : Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts ' , Journal of the American Heart Association , vol. 10 , no. 23 , 021995 . https://doi.org/10.1161/JAHA.121.021995

Title: Metabolic Biomarker Discovery for Risk of Peripheral Artery Disease Compared With Coronary Artery Disease : Lipoprotein and Metabolite Profiling of 31 657 Individuals From 5 Prospective Cohorts
Author: Tikkanen, Emmi; Jagerroos, Vilma; Holmes, Michael; Sattar, Naveed; Ala-Korpela, Mika; Jousilahti, Pekka; Lundqvist, Annamari; Perola, Markus; Salomaa, Veikko; Wurtz, Peter
Contributor organization: CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2021-12-07
Language: eng
Number of pages: 30
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
DOI: https://doi.org/10.1161/JAHA.121.021995
URI: http://hdl.handle.net/10138/338095
Abstract: Background Peripheral artery disease (PAD) and coronary artery disease (CAD) represent atherosclerosis in different vascular beds. We used detailed metabolic biomarker profiling to identify common and discordant biomarkers and clarify pathophysiological differences for these vascular diseases. Methods and Results We used 5 prospective cohorts from Finnish population (FINRISK 1997, 2002, 2007, and 2012, and Health 2000; n=31 657; median follow-up time of 14 years) to estimate associations between >200 metabolic biomarkers and incident PAD and CAD. Metabolic biomarkers were measured with nuclear magnetic resonance, and disease events were obtained from nationwide hospital records. During the follow-up, 498 incident PAD and 2073 incident CAD events occurred. In age- and sex-adjusted Cox models, apolipoproteins and cholesterol measures were robustly associated with incident CAD (eg, hazard ratio [HR] per SD for higher apolipoprotein B/A-1 ratio, 1.30; 95% CI, 1.25-1.36), but not with incident PAD (HR per SD for higher apolipoprotein B/A-1 ratio, 1.04; 95% CI, 0.95-1.14; P-heterogeneity0.05). Lower proportion of polyunsaturated fatty acids relative to total fatty acids, and higher concentrations of monounsaturated fatty acids, glycolysis-related metabolites, and inflammatory protein markers were strongly associated with incident PAD, and many of these associations were stronger for PAD than for CAD (P-heterogeneity
Subject: biomarker
coronary artery disease
magnetic resonance spectroscopy
metabolomics
peripheral artery disease
HOSPITAL DISCHARGE REGISTER
MAGNETIC-RESONANCE METABOLOMICS
EPIDEMIOLOGY
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
JAHA.121.021995.pdf 2.156Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record