The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis

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Tukia , E , Wagner , B , Vainio , K , Mönki , J & Kareskoski , M 2021 , ' The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis ' , Journal of Equine Veterinary Science , vol. 98 , 103365 . https://doi.org/10.1016/j.jevs.2020.103365

Title: The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis
Author: Tukia, Elina; Wagner, Bettina; Vainio, Kirsi; Mönki, Jenni; Kareskoski, Maria
Contributor organization: Production Animal Hospital
Production Animal Medicine
Equine and Small Animal Medicine
Equine Hospital
Animal Reproduction Science
Helsinki One Health (HOH)
Date: 2021-03
Language: eng
Number of pages: 6
Belongs to series: Journal of Equine Veterinary Science
ISSN: 0737-0806
DOI: https://doi.org/10.1016/j.jevs.2020.103365
URI: http://hdl.handle.net/10138/338102
Abstract: Postpartum metritis in mares is a life-threatening condition associated with severe clinical signs due to endotoxemia, and it is often followed by complications such as laminitis. Repeated large-volume uterine lavages are commonly recommended as a part of the treatment protocol to remove endotoxin-laden contents from the uterus. It has, however, also been suggested that lavages may increase the uptake of endotoxin into the circulation, leading to a deterioration of clinical signs. Endotoxemia is associated with the release of a multitude of inflammatory mediators regulating the immune response. The aim of this study was to evaluate if uterine lavage influences serum levels of the inflammation markers soluble CD14 (sCD14), chemokine (C-C motif) ligand 2 (CCL2), and interleukin (IL)-10 in mares with postpartum metritis. Serum samples were collected from eight mares treated for metritis at a university teaching hospital. Mares with fever, tachycardia, and/or leukopenia and hemosanguineous or purulent intrauterine fluid within 1 week of foaling were included in the study. Serum samples were taken before uterine lavage and 15 and 30 minutes after starting the lavage. The concentrations of sCD14, CCL2, and IL 10 were determined with a fluorescent beadebased immunoassay. There were no significant differences between sCD14, CCL2, or IL-10 levels at different sampling times. Heart rate was significantly lower after uterine lavage than before. The differences in body temperature and leukocyte count before and after lavage were not significant. In conclusion, uterine lavage had no immediate effect on the serum concentration of sCD14, CCL2, or IL-10, nor did it affect clinical parameters negatively. (c) 2020 Elsevier Inc. All rights reserved.
Subject: Equine
Postpartum metritis
Soluble CD14 sCD14)
Chemokine ligand 2 (CCL2)
Interleukin-10 (IL-10)
Retained fetal membranes
413 Veterinary science
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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