Variation near MTNR1A associates with early development and interacts with seasons

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http://hdl.handle.net/10138/338120

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Sulkava , S M , Taka , A-M , Kantojärvi , K , Pölkki , P , Morales-Munoz , I , Milani , L , Porkka-Heiskanen , T , Saarenpää-Heikkilä , O , Kylliäinen , A , Paavonen , E J & Paunio , T 2020 , ' Variation near MTNR1A associates with early development and interacts with seasons ' , Journal of Sleep Research , vol. 29 , no. 6 , 12925 . https://doi.org/10.1111/jsr.12925

Title: Variation near MTNR1A associates with early development and interacts with seasons
Author: Sulkava, Sonja M; Taka, Antti-Mathias; Kantojärvi, Katri; Pölkki, Pirjo; Morales-Munoz, Isabel; Milani, Lili; Porkka-Heiskanen, Tarja; Saarenpää-Heikkilä, Outi; Kylliäinen, Anneli; Paavonen, E. Juulia; Paunio, Tiina
Contributor organization: HUS Psychiatry
Department of Psychiatry
SLEEPWELL Research Program
Research Programs Unit
Faculty of Medicine
University of Helsinki
Medicum
Department of Physiology
HUS Children and Adolescents
Children's Hospital
Lastenpsykiatria
Date: 2020-12
Language: eng
Number of pages: 9
Belongs to series: Journal of Sleep Research
ISSN: 0962-1105
DOI: https://doi.org/10.1111/jsr.12925
URI: http://hdl.handle.net/10138/338120
Abstract: Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift‐work. Furthermore, this variant has been connected to Alzheimer's disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, we studied here the association of rs12506228 with early development. The study sample comprised 8‐month‐old infants from the Finnish CHILD‐SLEEP birth cohort (n = 1,301). Parental questionnaires assessed socioemotional, communication and motor development, as well as sleep length and night awakenings. The A allele of rs12506228 showed an association with slower socioemotional (p = .025) and communication (p = .0098) development, but no direct association with sleep. However, the association of the Finnish seasons with infant sleep length interacted with rs12506228. Taken together, rs12506228 near MTNR1A, which has been previously linked to adult and elderly traits, is shown here to associate with slower early cognitive development. In addition, these results suggest that the darker seasons associate with longer infant sleep time, but only in the absence of the rs12506228 AA genotype. Because the risk allele has been connected to fewer brain MT1 melatonin receptors, these associations may reflect the influence of decreased melatonin signalling in early development.
Subject: 3123 Gynaecology and paediatrics
sleep
infants
MELATONIN
cognitive development
genetics
infants
MTNR1A
seasonal variation
sleep
INFANT SLEEP PROBLEMS
SERUM MELATONIN
1ST YEAR
BRAIN
CHILDREN
GROWTH
RISK
POPULATION
COGNITION
PATTERNS
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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