Associations of PTEN and ERG with Magnetic Resonance Imaging Visibility and Assessment of Non–organ-confined Pathology and Biochemical Recurrence After Radical Prostatectomy

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Eineluoto , J T , Sandeman , K , Pohjonen , J , Sopyllo , K , Nordling , S , Stürenberg , C , Malén , A , Kilpeläinen , T P , Santti , H , Petas , A , Matikainen , M , Pellinen , T , Järvinen , P , Kenttämies , A , Rannikko , A & Mirtti , T 2021 , ' Associations of PTEN and ERG with Magnetic Resonance Imaging Visibility and Assessment of Non–organ-confined Pathology and Biochemical Recurrence After Radical Prostatectomy ' , European Urology Focus , vol. 7 , no. 6 , pp. 1316-1323 . https://doi.org/10.1016/j.euf.2020.06.016

Title: Associations of PTEN and ERG with Magnetic Resonance Imaging Visibility and Assessment of Non–organ-confined Pathology and Biochemical Recurrence After Radical Prostatectomy
Author: Eineluoto, Juho T.; Sandeman, Kevin; Pohjonen, Joona; Sopyllo, Konrad; Nordling, Stig; Stürenberg, Carolin; Malén, Adrian; Kilpeläinen, Tuomas P.; Santti, Henrikki; Petas, Anssi; Matikainen, Mika; Pellinen, Teijo; Järvinen, Petrus; Kenttämies, Anu; Rannikko, Antti; Mirtti, Tuomas
Contributor organization: Research Program in Systems Oncology
Urologian yksikkö
University of Helsinki
Helsinki University Hospital Area
HUSLAB
Research Programs Unit
Department of Pathology
Medicum
HUS Abdominal Center
Department of Surgery
Institute for Molecular Medicine Finland
Precision Systems Medicine
Clinicum
HUS Medical Imaging Center
Department of Diagnostics and Therapeutics
Date: 2021-11
Language: eng
Number of pages: 8
Belongs to series: European Urology Focus
ISSN: 2405-4569
DOI: https://doi.org/10.1016/j.euf.2020.06.016
URI: http://hdl.handle.net/10138/338132
Abstract: Background: Diagnosing clinically significant prostate cancer (PCa) is challenging, but may be facilitated by biomarkers and multiparametric magnetic resonance imaging (MRI). Objective: To determine the association between biomarkers phosphatase and tensin homolog (PTEN) and ETS-related gene (ERG) with visible and invisible PCa lesions in MRI, and to predict biochemical recurrence (BCR) and non-organ-confined (non-OC) PCa by integrating clinical, MRI, and biomarker-related data. Design, setting, and participants: A retrospective analysis of a population-based cohort of men with PCa, who underwent preoperative MRI followed by radical prostatectomy (RP) during 2014-2015 in Helsinki University Hospital (n = 346), was conducted. A tissue microarray corresponding to the MRI-visible and MRI-invisible lesions in RP specimens was constructed and stained for PTEN and ERG. Outcome measurements and statistical analysis: Associations of PTEN and ERG with MRI-visible and MRI-invisible lesions were examined (Pearson's chi 2 test), and predictions of non-OC disease together with clinical and MRI parameters were determined (area under the receiver operating characteristic curve and logistic regression analyses). BCR prediction was analyzed by Kaplan-Meier and Cox proportional hazard analyses. Results and limitations: Patients with MRI-invisible lesions (n = 35) had less PTEN loss and ERG-positive expression compared with patients (n = 90) with MRI-visible lesions (17.2% vs 43.3% [p = 0.006]; 8.6% vs 20.0% [p = 0.125]). Patients with invisible lesions had better, but not statistically significantly improved, BCR-free survival probability in Kaplan-Meier analyses (p = 0.055). Rates of BCR (5.7% vs 21.1%; p = 0.039), extraprostatic extension (11.4% vs 44.6%; p < 0.001), seminal vesicle invasion (0% vs 21.1%; p = 0.003), and lymph node metastasis (0% vs 12.2%; p = 0.033) differed between the groups in favor of patients with MRI-invisible lesions. Biomarkers had no independent role in predicting non-OC disease or BCR. The short follow-up period was a limitation. Conclusions: PTEN loss, BCR, and non-OC RP findings were more often encountered with MRI-visible lesions. Patient summary: Magnetic resonance imaging (MRI) of the prostate misses some cancer lesions. MRI-invisible lesions seem to be less aggressive than MRI-visible lesions. (C) 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Subject: 3126 Surgery, anesthesiology, intensive care, radiology
Biomarkers
ERG
Multiparametric magnetic resonance imaging
Prostate Imaging Reporting and
Data System
Prostate cancer
PTEN
Radical prostatectomy
CANCER
EXPRESSION
GUIDELINES
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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