Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Show full item record



Korpela , K , Kallio , S , Salonen , A , Hero , M , Kukkonen , A K , Miettinen , P J , Savilahti , E , Kohva , E , Kariola , L , Suutela , M , Tarkkanen , A , de Vos , W M , Raivio , T & Kuitunen , M 2021 , ' Gut microbiota develop towards an adult profile in a sex-specific manner during puberty ' , Scientific Reports , vol. 11 , no. 1 , 23297 .

Title: Gut microbiota develop towards an adult profile in a sex-specific manner during puberty
Author: Korpela, Katri; Kallio, Sampo; Salonen, Anne; Hero, Matti; Kukkonen, Anna Kaarina; Miettinen, Päivi J.; Savilahti, Erkki; Kohva, Ella; Kariola, Laura; Suutela, Maria; Tarkkanen, Annika; de Vos, Willem M.; Raivio, Taneli; Kuitunen, Mikael
Contributor organization: HUMI - Human Microbiome Research
Children's Hospital
HUS Children and Adolescents
Faculty Common Matters (Faculty of Biology and Environmental Sciences)
de Vos & Salonen group
Raivio Group
Centre of Excellence in Stem Cell Metabolism
Timo Pyry Juhani Otonkoski / Principal Investigator
Research Programs Unit
Lastentautien yksikkö
Department of Bacteriology and Immunology
Willem Meindert Vos de / Principal Investigator
STEMM - Stem Cells and Metabolism Research Program
Date: 2021-12-02
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
Abstract: Accumulating evidence indicates that gut microbiota may regulate sex-hormone levels in the host, with effects on reproductive health. Very little is known about the development of intestinal microbiota during puberty in humans. To assess the connection between pubertal timing and fecal microbiota, and to assess how fecal microbiota develop during puberty in comparison with adult microbiota, we utilized a Finnish allergy-prevention-trial cohort (Flora). Data collected at 13-year follow-up were compared with adult data from a different Finnish cohort. Among the 13-year-old participants we collected questionnaire information, growth data from school-health-system records and fecal samples from 148 participants. Reference adult fecal samples were received from the Health and Early Life Microbiota (HELMi) cohort (n=840). Fecal microbiota were analyzed using 16S rRNA gene amplicon sequencing; the data were correlated with pubertal timing and compared with data on adult microbiota. Probiotic intervention in the allergy-prevention-trial cohort was considered as a confounding factor only. The main outcome was composition of the microbiota in relation to pubertal timing (time to/from peak growth velocity) in both sexes separately, and similarity to adult microbiota. In girls, fecal microbiota became more adult-like with pubertal progression (p= 0.009). No such development was observed in boys (p = 0.9). Both sexes showed a trend towards increasing relative abundance of estrogen-metabolizing Clostridia and decreasing Bacteroidia with pubertal development, but this was statistically significant in girls only (p = 0.03). In girls, pubertal timing was associated positively with exposure to cephalosporins prior to the age of 10. Our data support the hypothesis that gut microbiota, particularly members of Ruminococcaceae, may affect pubertal timing, possibly via regulating host sex-hormone levels.
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_021_02375_z.pdf 3.503Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record