APOE epsilon 4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue : a Finnish biobank, autopsy and clinical study

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FinnGen , Kurki , S N , Kantonen , J , Kaivola , K , Hokkanen , L , Mäyranpää , M I , Puttonen , H , Martola , J , Pöyhönen , M , Kero , M , Tuimala , J , Carpen , O , Kantele , A , Vapalahti , O , Tiainen , M , Tienari , P J , Kaila , K , Hastbacka , J & Myllykangas , L 2021 , ' APOE epsilon 4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue : a Finnish biobank, autopsy and clinical study ' , Acta Neuropathologica Communications , vol. 9 , 199 . https://doi.org/10.1186/s40478-021-01302-7

Title: APOE epsilon 4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue : a Finnish biobank, autopsy and clinical study
Author: FinnGen; Kurki, Samu N.; Kantonen, Jonas; Kaivola, Karri; Hokkanen, Laura; Mäyranpää, Mikko I.; Puttonen, Henri; Martola, Juha; Pöyhönen, Minna; Kero, Mia; Tuimala, Jarno; Carpen, Olli; Kantele, Anu; Vapalahti, Olli; Tiainen, Marjaana; Tienari, Pentti J.; Kaila, Kai; Hastbacka, Johanna; Myllykangas, Liisa
Contributor organization: Molecular and Integrative Biosciences Research Programme
HUSLAB
Faculty of Biological and Environmental Sciences
Department of Psychology and Logopedics
Behavioural Sciences
Department of Pathology
HUS Medical Imaging Center
Department of Medical and Clinical Genetics
Minna Pöyhönen / Principal Investigator
Olli Mikael Carpen / Principal Investigator
Precision Cancer Pathology
Department of Medicine
Department of Virology
Veterinary Biosciences
Veterinary Microbiology and Epidemiology
Helsinki One Health (HOH)
Viral Zoonosis Research Unit
Olli Pekka Vapalahti / Principal Investigator
HUS Neurocenter
Clinicum
Department of Neurosciences
Neuroscience Center
Kai Kaila / Principal Investigator
Laboratory of Neurobiology
HUS Perioperative, Intensive Care and Pain Medicine
Date: 2021-12-23
Language: eng
Number of pages: 13
Belongs to series: Acta Neuropathologica Communications
ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-021-01302-7
URI: http://hdl.handle.net/10138/338308
Abstract: Apolipoprotein E epsilon 4 allele (APOE4) has been shown to associate with increased susceptibility to SARS-CoV-2 infection and COVID-19 mortality in some previous genetic studies, but information on the role of APOE4 on the underlying pathology and parallel clinical manifestations is scarce. Here we studied the genetic association between APOE and COVID-19 in Finnish biobank, autopsy and prospective clinical cohort datasets. In line with previous work, our data on 2611 cases showed that APOE4 carriership associates with severe COVID-19 in intensive care patients compared with non-infected population controls after matching for age, sex and cardiovascular disease status. Histopathological examination of brain autopsy material of 21 COVID-19 cases provided evidence that perivascular microhaemorrhages are more prevalent in APOE4 carriers. Finally, our analysis of post-COVID fatigue in a prospective clinical cohort of 156 subjects revealed that APOE4 carriership independently associates with higher mental fatigue compared to non-carriers at six months after initial illness. In conclusion, the present data on Finns suggests that APOE4 is a risk factor for severe COVID-19 and post-COVID mental fatigue and provides the first indication that some of this effect could be mediated via increased cerebrovascular damage. Further studies in larger cohorts and animal models are warranted.
Subject: APOE4
COVID-19 sequelae
Brain microhaemorrhage
Post-viral fatigue
Neuropathology
SARS-CoV-2
Biobank
APOE
NEUROPATHOLOGY
DISEASE
3112 Neurosciences
515 Psychology
Neuropsychology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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