Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children

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DIABIMMUNE Study Grp , Reinert-Hartwall , L , Siljander , H , Härkönen , T , Vatanen , T , Ilonen , J , Niemelä , O , Luopajärvi , K , Dorshakova , N , Mokurov , S , Peet , A , Tillmann , V , Uibo , R , Knip , M , Vaarala , O & Honkanen , J 2022 , ' Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children ' , Pediatric Allergy and Immunology , vol. 33 , no. 1 . https://doi.org/10.1111/pai.13613

Title: Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children
Author: DIABIMMUNE Study Grp; Reinert-Hartwall, Linnea; Siljander, Heli; Härkönen, Taina; Vatanen, Tommi; Ilonen, Jorma; Niemelä, Onni; Luopajärvi, Kristiina; Dorshakova, Natalya; Mokurov, Sergei; Peet, Aleksandr; Tillmann, Vallo; Uibo, Raivo; Knip, Mikael; Vaarala, Outi; Honkanen, Jarno
Contributor organization: Research Programs Unit
TRIMM - Translational Immunology Research Program
HUS Children and Adolescents
Children's Hospital
CAMM - Research Program for Clinical and Molecular Metabolism
Molecular and Integrative Biosciences Research Programme
Date: 2022-01
Language: eng
Number of pages: 9
Belongs to series: Pediatric Allergy and Immunology
ISSN: 0905-6157
DOI: https://doi.org/10.1111/pai.13613
URI: http://hdl.handle.net/10138/338561
Abstract: Background Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load. Methods We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases. Results We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses. Conclusion Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.
Subject: allergic sensitization
epidermal growth factor
epithelial integrity
T helper cell
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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