Regulation of spatial distribution of BMP ligands for pattern formation

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Montanari , M P , Tran , N V & Shimmi , O 2022 , ' Regulation of spatial distribution of BMP ligands for pattern formation ' , Developmental Dynamics , vol. 251 , no. 1 , pp. 198-212 . https://doi.org/10.1002/dvdy.397

Title: Regulation of spatial distribution of BMP ligands for pattern formation
Author: Montanari, Martti P.; Tran, Ngan Vi; Shimmi, Osamu
Contributor organization: Institute of Biotechnology
Morphogenesis and cellular dynamics
Biosciences
Date: 2022-01
Language: eng
Number of pages: 15
Belongs to series: Developmental Dynamics
ISSN: 1058-8388
DOI: https://doi.org/10.1002/dvdy.397
URI: http://hdl.handle.net/10138/338563
Abstract: Bone morphogenetic proteins (BMPs), members of the transforming growth factor-ss (TGF-ss) family, have been shown to contribute to embryogenesis and organogenesis during animal development. Relevant studies provide support for the following concepts: (a) BMP signals are evolutionarily highly conserved as a genetic toolkit; (b) spatiotemporal distributions of BMP signals are precisely controlled at the post-translational level; and (c) the BMP signaling network has been co-opted to adapt to diversified animal development. These concepts originated from the historical findings of the Spemann-Mangold organizer and the subsequent studies about how this organizer functions at the molecular level. In this Commentary, we focus on two topics. First, we review how the BMP morphogen gradient is formed to sustain larval wing imaginal disc and early embryo growth and patterning in Drosophila. Second, we discuss how BMP signal is tightly controlled in a context-dependent manner, and how the signal and tissue dynamics are coupled to facilitate complex tissue structure formation. Finally, we argue how these concepts might be developed in the future for further understanding the significance of BMP signaling in animal development.
Subject: dpp
embryogenesis
morphogenesis
organogenesis
DPP MORPHOGEN GRADIENT
NEURAL-TUBE CLOSURE
TWISTED GASTRULATION
DECAPENTAPLEGIC GENE
II RECEPTOR
STEM-CELLS
DROSOPHILA
GROWTH
FATE
TRANSPORT
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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