Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density

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Ålgars , A , Kemppinen , L , Fair-Mäkelä , R , Mustonen , H , Haglund , C & Jalkanen , S 2021 , ' Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density ' , Cancers , vol. 13 , no. 23 , 5988 . https://doi.org/10.3390/cancers13235988

Title: Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density
Author: Ålgars, Annika; Kemppinen, Lotta; Fair-Mäkelä, Ruth; Mustonen, Harri; Haglund, Caj; Jalkanen, Sirpa
Contributor organization: HUS Abdominal Center
Clinicum
Department of Surgery
CAN-PRO - Translational Cancer Medicine Program
Faculty of Medicine
II kirurgian klinikka
Date: 2021-12
Language: eng
Number of pages: 16
Belongs to series: Cancers
ISSN: 2072-6694
DOI: https://doi.org/10.3390/cancers13235988
URI: http://hdl.handle.net/10138/338619
Abstract: Simple Summary Tumor-associated macrophages can either promote or prevent cancer growth depending on factors such as macrophage polarization status, tumor type, and disease stage. Macrophages and vessels interact with each other, and the number of lymphatic vessels also affects cancer survival. CLEVER-1 is a protein expressed both on immunosuppressive M2 macrophages and lymphatic vessels. The aim of this study was to validate our previous results regarding the prognostic role of CLEVER-1(+) macrophages, CD68(+) macrophages, and CLEVER-1(+) lymphatic vessels in stage I-IV colorectal cancer. The results indicate that the prognostic role of tumor-associated macrophages and lymphatic vessels changes during disease progression. The findings resemble our earlier results, but are not completely equal, which may be due to the different types of tumor samples used in the two studies (whole section vs. tissue microarray). Macrophages, which are key players in the tumor microenvironment and affect the prognosis of many cancers, interact with lymphatic vessels in tumor tissue. However, the prognostic role of tumor-associated macrophages (TAM) and lymphatic vessels in human colorectal cancer (CRC) remains controversial. We investigated the prognostic role of CD68(+) and CLEVER-1(+) (common lymphatic endothelial and vascular endothelial receptor 1) TAMs in addition to CLEVER-1(+) lymphatic vessels in 498 stage I-IV CRC patients. The molecular markers were detected by immunohistochemical (IHC) analysis. The results showed that, in early stage I CRC and in young patients (age below median,
Subject: colorectal cancer
macrophage
lymphatic vessel
CD68
CLEVER-1
survival
TUMOR-ASSOCIATED MACROPHAGES
ANTIBODY ANTI-CLEVER-1 MAB
MICROSATELLITE INSTABILITY
LYMPHATIC VESSELS
POOR-PROGNOSIS
PD-1 BLOCKADE
INFILTRATION
POLARIZATION
ACTIVATION
NIVOLUMAB
3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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