Implications of Gut Microbiota in Complex Human Diseases

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Yu , D , Meng , X , de Vos , W M , Wu , H , Fang , X & Maiti , A K 2021 , ' Implications of Gut Microbiota in Complex Human Diseases ' , International Journal of Molecular Sciences , vol. 22 , no. 23 , 12661 . https://doi.org/10.3390/ijms222312661

Title: Implications of Gut Microbiota in Complex Human Diseases
Author: Yu, Dahai; Meng, Xin; de Vos, Willem M.; Wu, Hao; Fang, Xuexun; Maiti, Amit K.
Contributor organization: Willem Meindert Vos de / Principal Investigator
de Vos & Salonen group
Research Programs Unit
HUMI - Human Microbiome Research
Date: 2021-12
Language: eng
Number of pages: 33
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms222312661
URI: http://hdl.handle.net/10138/338635
Abstract: Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases.
Subject: gut
microbiota
disease
bacteria
FMT
CHAIN FATTY-ACIDS
BIFIDOBACTERIUM-LONGUM NCC3001
HELICOBACTER-PYLORI INFECTION
DIET-INDUCED OBESITY
FECAL MICROBIOTA
FUSOBACTERIUM-NUCLEATUM
COLORECTAL-CANCER
COLONIC INFLAMMATION
CAMPYLOBACTER-JEJUNI
METABOLITE BUTYRATE
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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