Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

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Mullins , N , Kang , J , Campos , A I , Coleman , J R I , Edwards , A C , Galfalvy , H , Levey , D F , Lori , A , Shabalin , A , Starnawska , A , Su , M-H , Watson , H J , Adams , M , Awasthi , S , Gandal , M , Hafferty , J D , Hishimoto , A , Kim , M , Okazaki , S , Otsuka , I , Ripke , S , Ware , E B , Bergen , A W , Berrettini , W H , Bohus , M , Brandt , H , Chang , X , Chen , W J , Chen , H-C , Crawford , S , Crow , S , DiBlasi , E , Duriez , P , Fernández-Aranda , F , Fichter , M M , Gallinger , S , Glatt , S J , Gorwood , P , Guo , Y , Hakonarson , H , Halmi , K A , Hwu , H-G , Jain , S , Jamain , S , Jiménez-Murcia , S , Johnson , C , Kaplan , A S , Kaye , W H , Keel , P K , Kennedy , J L , Klump , K L , Li , D , Liao , S-C , Lieb , K , Lilenfeld , L , Liu , C-M , Magistretti , P J , Marshall , C R , Mitchell , J E , Monson , E T , Myers , R M , Pinto , D , Powers , A , Ramoz , N , Roepke , S , Rozanov , V , Scherer , S W , Schmahl , C , Sokolowski , M , Strober , M , Thornton , L M , Treasure , J , Tsuang , M T , Witt , S H , Woodside , D B , Yilmaz , Z , Zillich , L , Adolfsson , R , Agartz , I , Air , T M , Alda , M , Alfredsson , L , Andreassen , O A , Anjorin , A , Appadurai , V , Soler Artigas , M , der Auwera , S V , Azevedo , M H , Bass , N , Bau , C H D , Baune , B T , Bellivier , F , Berger , K , Biernacka , J M , Bigdeli , T B , Binder , E B , Boehnke , M , Boks , M P , Bosch , R , Braff , D L , Bryant , R , Budde , M , Byrne , E M , Cahn , W , Casas , M , Castelao , E , Cervilla , J A , Chaumette , B , Cichon , S , Corvin , A , Craddock , N , Craig , D , Degenhardt , F , Djurovic , S , Edenberg , H J , Fanous , A H , Foo , J C , Forstner , A J , Frye , M , Fullerton , J M , Gatt , J M , Gejman , P V , Giegling , I , Grabe , H J , Green , M J , Grevet , E H , Grigoroiu-Serbanescu , M , Gutierrez , B , Guzman-Parra , J , Hamilton , S P , Hamshere , M L , Hartmann , A , Hauser , J , Heilmann-Heimbach , S , Hoffmann , P , Ising , M , Jones , I , Jones , L A , Jonsson , L , Kahn , R S , Kelsoe , J R , Kendler , K S , Kloiber , S , Koenen , K C , Kogevinas , M , Konte , B , Krebs , M-O , Landén , M , Lawrence , J , Leboyer , M , Lee , P H , Levinson , D F , Liao , C , Lissowska , J , Lucae , S , Mayoral , F , McElroy , S L , McGrath , P , McGuffin , P , McQuillin , A , Medland , S E , Mehta , D , Melle , I , Milaneschi , Y , Mitchell , P B , Molina , E , Morken , G , Mortensen , P B , Müller-Myhsok , B , Nievergelt , C M , Nimgaonkar , V , Nöthen , M M , O’Donovan , M C , Ophoff , R A , Owen , M J , Pato , C , Pato , M T , Penninx , B W J H , Pimm , J , Pistis , G , Potash , J B , Power , R A , Preisig , M , Quested , D , Ramos-Quiroga , J A , Reif , A , Ribasés , M , Richarte , V , Rietschel , M , Rivera , M , Roberts , A , Roberts , G , Rouleau , G A , Rovaris , D L , Rujescu , D , Sánchez-Mora , C , Sanders , A R , Schofield , P R , Schulze , T G , Scott , L J , Serretti , A , Shi , J , Shyn , S I , Sirignano , L , Sklar , P , Smeland , O B , Smoller , J W , Sonuga-Barke , E J S , Spalletta , G , Strauss , J S , Świątkowska , B , Trzaskowski , M , Turecki , G , Vilar-Ribó , L , Vincent , J B , Völzke , H , Walters , J T R , Shannon Weickert , C , Weickert , T W , Weissman , M M , Williams , L M , Wray , N R , Zai , C C , Ashley-Koch , A E , Beckham , J C , Hauser , E R , Hauser , M A , Kimbrel , N A , Lindquist , J H , McMahon , B , Oslin , D W , Qin , X , Mattheisen , M , Abdellaoui , A , Adams , M J , Agerbo , E , Andlauer , T F M , Bacanu , S-A , Bækvad-Hansen , M , Beekman , A T F , Bryois , J , Buttenschøn , H N , Bybjerg-Grauholm , J , Cai , N , Christensen , J H , Clarke , T-K , Colodro-Conde , L , Couvy-Duchesne , B , Craddock , N , Crawford , G E , Davies , G , Derks , E M , Direk , N , Dolan , C V , Dunn , E C , Eley , T C , Escott-Price , V , Hassan Kiadeh , F F , Finucane , H K , Frank , J , Gaspar , H A , Gill , M , Goes , F S , Gordon , S D , Weinsheimer , S M , Wellmann , J , Willemsen , G , Wu , Y , Xi , S , Yang , J , Zhang , F , Arolt , V , Boomsma , D I , Dannlowski , U , de Geus , E J C , Depaulo , J R , Domenici , E , Domschke , K , Esko , T , Grove , J , Hall , L S , Hansen , C S , Hansen , T F , Herms , S , Hickie , I B , Homuth , G , Horn , C , Hottenga , J-J , Hougaard , D M , Howard , D M , Jansen , R , Jorgenson , E , Knowles , J A , Kohane , I S , Kraft , J , Kretzschmar , W W , Kutalik , Z , Li , Y , Lind , P A , MacIntyre , D J , MacKinnon , D F , Maier , R M , Maier , W , Marchini , J , Mbarek , H , Middeldorp , C M , Mihailov , E , Milani , L , Mondimore , F M , Montgomery , G W , Mostafavi , S , Nauck , M , Ng , B , Nivard , M G , Nyholt , D R , O’Reilly , P F , Oskarsson , H , Hayward , C , Heath , A C , Lewis , G , Li , Q S , Madden , P A F , Magnusson , P K , Martin , N G , McIntosh , A M , Metspalu , A , Mors , O , Nordentoft , M , Paciga , S A , Pedersen , N L , Painter , J N , Pedersen , C B , Pedersen , M G , Peterson , R E , Peyrot , W J , Posthuma , D , Quiroz , J A , Qvist , P , Rice , J P , Riley , B P , Mirza , S S , Schoevers , R , Schulte , E C , Shen , L , Sigurdsson , E , Sinnamon , G C B , Smit , J H , Smith , D J , Stefansson , H , Steinberg , S , Streit , F , Strohmaier , J , Tansey , K E , Teismann , H , Teumer , A , Thompson , W , Thomson , P A , Thorgeirsson , T E , Traylor , M , Treutlein , J , Trubetskoy , V , Uitterlinden , A G , Umbricht , D , der Auwera , S V , van Hemert , A M , Viktorin , A , Visscher , P M , Wang , Y , Webb , B T , Perlis , R H , Porteous , D J , Schaefer , C , Stefansson , K , Tiemeier , H , Uher , R , Werge , T , Lewis , C M , Breen , G , Børglum , A D , Sullivan , P F , O’Connell , K S , Coombes , B , Qiao , Z , Als , T D , Børte , S , Charney , A W , Drange , O K , Gandal , M J , Hagenaars , S P , Ikeda , M , Kamitaki , N , Krebs , K , Panagiotaropoulou , G , Schilder , B M , Sloofman , L G , Winsvold , B S , Won , H-H , Abramova , L , Adorjan , K , Al Eissa , M , Albani , D , Alliey-Rodriguez , N , Antilla , V , Antoniou , A , Baek , J H , Bauer , M , Beins , E C , Bergen , S E , Birner , A , Bøen , E , Brum , M , Brumpton , B M , Brunkhorst-Kanaan , N , Byerley , W , Cairns , M , Casas , M , Cervantes , P , Cruceanu , C , Cuellar-Barboza , A , Cunningham , J , Curtis , D , Czerski , P M , Dale , A M , Dalkner , N , David , F S , Dobbyn , A L , Douzenis , A , Elvsåshagen , T , Ferrier , I N , Fiorentino , A , Foroud , T M , Forty , L , Frei , O , Freimer , N B , Frisén , L , Gade , K , Garnham , J , Gelernter , J , Gizer , I R , Gordon-Smith , K , Greenwood , T A , Guzman-Parra , J , Ha , K , Haraldsson , M , Hautzinger , M , Heilbronner , U , Hellgren , D , Holmans , P A , Huckins , L , Johnson , J S , Kalman , J L , Kamatani , Y , Kittel-Schneider , S , Koromina , M , Kranz , T M , Kranzler , H R , Kubo , M , Kupka , R , Kushner , S A , Lavebratt , C , Leber , M , Lee , H-J , Levy , S E , Lewis , C , Lundberg , M , Magnusson , S H , Maihofer , A , Malaspina , D , Maratou , E , Martinsson , L , McGregor , N W , McKay , J D , Medeiros , H , Millischer , V , Moran , J L , Morris , D W , Mühleisen , T W , O’Brien , N , O’Donovan , C , Olde Loohuis , L M , Oruc , L , Papiol , S , Pardiñas , A F , Perry , A , Pfennig , A , Porichi , E , Raj , T , Rapaport , M H , DePaulo , J R , Regeer , E J , Rivas , F , Roth , J , Roussos , P , Ruderfer , D M , Senner , F , Sharp , S , Shilling , P D , Slaney , C , Sobell , J L , Artigas , M S , Spijker , A T , Stein , D J , Terao , C , Toma , C , Tooney , P , Tsermpini , E-E , Vawter , M P , Vedder , H , Xi , S , Xu , W , Kay Yang , J M , Young , A H , Young , H , Zandi , P P , Zhou , H , Psychiatry , HUNT A-I , Babadjanova , G , Backlund , L , Bengesser , S , Blackwood , D H R , Carr , V J , Catts , S , Dikeos , D , Etain , B , Ferentinos , P , Gawlik , M , Gershon , E S , Henskens , F , Hillert , J , Hong , K S , Hultman , C M , Hveem , K , Iwata , N , Jablensky , A V , Kirov , G , Lochner , C , Loughland , C , Mathews , C A , McMahon , F J , Michie , P , Mowry , B , Neale , B M , Nievergelt , C M , Oedegaard , K J , Olsson , T , Pantelis , C , Patrinos , G P , Reininghaus , E Z , Saito , T , Schall , U , Schalling , M , Scott , R J , Weickert , C S , Stordal , E , Vaaler , A E , Vieta , E , Waldman , I D , Zwart , J-A , Nurnberger , J I , Stahl , E A , Di Florio , A , Adan , R A H , Ando , T , Aschauer , H , Baker , J H , Bencko , V , Birgegård , A , Boden , J M , Boehm , I , Boni , C , Perica , V B , Buehren , K , Bulik , C M , Burghardt , R , Carlberg , L , Cassina , M , Clementi , M , Cone , R D , Courtet , P , Crowley , J J , Danner , U N , Davis , O S P , de Zwaan , M , Dedoussis , G , Degortes , D , DeSocio , J E , Dick , D M , Dina , C , Dmitrzak-Weglarz , M , Martinez , E D , Duncan , L E , Egberts , K , Mattingsdal , M , McDevitt , S , Meulenbelt , I , Micali , N , Mitchell , J , Mitchell , K , Monteleone , P , Monteleone , A M , Munn-Chernoff , M A , Nacmias , B , Navratilova , M , Ntalla , I , Olsen , C M , O’Toole , J K , Padyukov , L , Palotie , A , Pantel , J , Papezova , H , Parker , R , Pearson , J F , Ehrlich , S , Escaramís , G , Espeseth , T , Estivill , X , Farmer , A , Favaro , A , Fischer , K , Floyd , J A B , Föcker , M , Foretova , L , Forzan , M , Franklin , C S , Gambaro , G , Giuranna , J , Giusti-Rodríquez , P , Gonidakis , F , Gordon , S , Mayora , M G , Guillaume , S , Hanscombe , K B , Hatzikotoulas , K , Hebebrand , J , Helder , S G , Henders , A K , Herpertz-Dahlmann , B , Herzog , W , Hinney , A , Horwood , L J , Hübel , C , Petersen , L V , Purves , K L , Raevuori , A , Reichborn-Kjennerud , T , Ricca , V , Ripatti , S , Ritschel , F , Roberts , M , Rybakowski , F , Santonastaso , P , Scherag , A , Schmidt , U , Schork , N J , Schosser , A , Seitz , J , Slachtova , L , Slagboom , P E , Slof-Op ‘t Landt , M C T , Slopien , A , Soranzo , N , Sorbi , S , Southam , L , Steen , V W , Huckins , L M , Hudson , J I , Imgart , H 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Title: Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Author: Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J.; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan D.; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ripke, Stephan; Ware, Erin B.; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J.; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fernández-Aranda, Fernando; Fichter, Manfred M.; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A.; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stéphane; Jiménez-Murcia, Susana; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Keel, Pamela K.; Kennedy, James L.; Klump, Kelly L.; Li, Dong; Liao, Shih-Cheng; Lieb, Klaus; Lilenfeld, Lisa; Liu, Chih-Min; Magistretti, Pierre J.; Marshall, Christian R.; Mitchell, James E.; Monson, Eric T.; Myers, Richard M.; Pinto, Dalila; Powers, Abigail; Ramoz, Nicolas; Roepke, Stefan; Rozanov, Vsevolod; Scherer, Stephen W.; Schmahl, Christian; Sokolowski, Marcus; Strober, Michael; Thornton, Laura M.; Treasure, Janet; Tsuang, Ming T.; Witt, Stephanie H.; Woodside, D. Blake; Yilmaz, Zeynep; Zillich, Lea; Adolfsson, Rolf; Agartz, Ingrid; Air, Tracy M.; Alda, Martin; Alfredsson, Lars; Andreassen, Ole A.; Anjorin, Adebayo; Appadurai, Vivek; Soler Artigas, María; der Auwera, Sandra Van; Azevedo, M. Helena; Bass, Nicholas; Bau, Claiton H.D.; Baune, Bernhard T.; Bellivier, Frank; Berger, Klaus; Biernacka, Joanna M.; Bigdeli, Tim B.; Binder, Elisabeth B.; Boehnke, Michael; Boks, Marco P.; Bosch, Rosa; Braff, David L.; Bryant, Richard; Budde, Monika; Byrne, Enda M.; Cahn, Wiepke; Casas, Miguel; Castelao, Enrique; Cervilla, Jorge A.; Chaumette, Boris; Cichon, Sven; Corvin, Aiden; Craddock, Nicholas; Craig, David; Degenhardt, Franziska; Djurovic, Srdjan; Edenberg, Howard J.; Fanous, Ayman H.; Foo, Jerome C.; Forstner, Andreas J.; Frye, Mark; Fullerton, Janice M.; Gatt, Justine M.; Gejman, Pablo V.; Giegling, Ina; Grabe, Hans J.; Green, Melissa J.; Grevet, Eugenio H.; Grigoroiu-Serbanescu, Maria; Gutierrez, Blanca; Guzman-Parra, Jose; Hamilton, Steven P.; Hamshere, Marian L.; Hartmann, Annette; Hauser, Joanna; Heilmann-Heimbach, Stefanie; Hoffmann, Per; Ising, Marcus; Jones, Ian; Jones, Lisa A.; Jonsson, Lina; Kahn, René S.; Kelsoe, John R.; Kendler, Kenneth S.; Kloiber, Stefan; Koenen, Karestan C.; Kogevinas, Manolis; Konte, Bettina; Krebs, Marie-Odile; Landén, Mikael; Lawrence, Jacob; Leboyer, Marion; Lee, Phil H.; Levinson, Douglas F.; Liao, Calwing; Lissowska, Jolanta; Lucae, Susanne; Mayoral, Fermin; McElroy, Susan L.; McGrath, Patrick; McGuffin, Peter; McQuillin, Andrew; Medland, Sarah E.; Mehta, Divya; Melle, Ingrid; Milaneschi, Yuri; Mitchell, Philip B.; Molina, Esther; Morken, Gunnar; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Nievergelt, Caroline M.; Nimgaonkar, Vishwajit; Nöthen, Markus M.; O’Donovan, Michael C.; Ophoff, Roel A.; Owen, Michael J.; Pato, Carlos; Pato, Michele T.; Penninx, Brenda W.J.H.; Pimm, Jonathan; Pistis, Giorgio; Potash, James B.; Power, Robert A.; Preisig, Martin; Quested, Digby; Ramos-Quiroga, Josep Antoni; Reif, Andreas; Ribasés, Marta; Richarte, Vanesa; Rietschel, Marcella; Rivera, Margarita; Roberts, Andrea; Roberts, Gloria; Rouleau, Guy A.; Rovaris, Diego L.; Rujescu, Dan; Sánchez-Mora, Cristina; Sanders, Alan R.; Schofield, Peter R.; Schulze, Thomas G.; Scott, Laura J.; Serretti, Alessandro; Shi, Jianxin; Shyn, Stanley I.; Sirignano, Lea; Sklar, Pamela; Smeland, Olav B.; Smoller, Jordan W.; Sonuga-Barke, Edmund J.S.; Spalletta, Gianfranco; Strauss, John S.; Świątkowska, Beata; Trzaskowski, Maciej; Turecki, Gustavo; Vilar-Ribó, Laura; Vincent, John B.; Völzke, Henry; Walters, James T.R.; Shannon Weickert, Cynthia; Weickert, Thomas W.; Weissman, Myrna M.; Williams, Leanne M.; Wray, Naomi R.; Zai, Clement C.; Ashley-Koch, Allison E.; Beckham, Jean C.; Hauser, Elizabeth R.; Hauser, Michael A.; Kimbrel, Nathan A.; Lindquist, Jennifer H.; McMahon, Benjamin; Oslin, David W.; Qin, Xuejun; Mattheisen, Manuel; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Andlauer, Till F.M.; Bacanu, Silviu-Alin; Bækvad-Hansen, Marie; Beekman, Aartjan T.F.; Bryois, Julien; Buttenschøn, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na; Christensen, Jane Hvarregaard; Clarke, Toni-Kim; Colodro-Conde, Lucía; Couvy-Duchesne, Baptiste; Craddock, Nick; Crawford, Gregory E.; Davies, Gail; Derks, Eske M.; Direk, Nese; Dolan, Conor V.; Dunn, Erin C.; Eley, Thalia C.; Escott-Price, Valentina; Hassan Kiadeh, Farnush Farhadi; Finucane, Hilary K.; Frank, Josef; Gaspar, Héléna A.; Gill, Michael; Goes, Fernando S.; Gordon, Scott D.; Weinsheimer, Shantel Marie; Wellmann, Jürgen; Willemsen, Gonneke; Wu, Yang; Xi, Simon; Yang, Jian; Zhang, Futao; Arolt, Volker; Boomsma, Dorret I.; Dannlowski, Udo; de Geus, E.J.C.; Depaulo, J. Raymond; Domenici, Enrico; Domschke, Katharina; Esko, Tõnu; Grove, Jakob; Hall, Lynsey S.; Hansen, Christine Søholm; Hansen, Thomas F.; Herms, Stefan; Hickie, Ian B.; Homuth, Georg; Horn, Carsten; Hottenga, Jouke-Jan; Hougaard, David M.; Howard, David M.; Jansen, Rick; Jorgenson, Eric; Knowles, James A.; Kohane, Isaac S.; Kraft, Julia; Kretzschmar, Warren W.; Kutalik, Zoltán; Li, Yihan; Lind, Penelope A.; MacIntyre, Donald J.; MacKinnon, Dean F.; Maier, Robert M.; Maier, Wolfgang; Marchini, Jonathan; Mbarek, Hamdi; Middeldorp, Christel M.; Mihailov, Evelin; Milani, Lili; Mondimore, Francis M.; Montgomery, Grant W.; Mostafavi, Sara; Nauck, Matthias; Ng, Bernard; Nivard, Michel G.; Nyholt, Dale R.; O’Reilly, Paul F.; Oskarsson, Hogni; Hayward, Caroline; Heath, Andrew C.; Lewis, Glyn; Li, Qingqin S.; Madden, Pamela A.F.; Magnusson, Patrik K.; Martin, Nicholas G.; McIntosh, Andrew M.; Metspalu, Andres; Mors, Ole; Nordentoft, Merete; Paciga, Sara A.; Pedersen, Nancy L.; Painter, Jodie N.; Pedersen, Carsten Bøcker; Pedersen, Marianne Giørtz; Peterson, Roseann E.; Peyrot, Wouter J.; Posthuma, Danielle; Quiroz, Jorge A.; Qvist, Per; Rice, John P.; Riley, Brien P.; Mirza, Saira Saeed; Schoevers, Robert; Schulte, Eva C.; Shen, Ling; Sigurdsson, Engilbert; Sinnamon, Grant C.B.; Smit, Johannes H.; Smith, Daniel J.; Stefansson, Hreinn; Steinberg, Stacy; Streit, Fabian; Strohmaier, Jana; Tansey, Katherine E.; Teismann, Henning; Teumer, Alexander; Thompson, Wesley; Thomson, Pippa A.; Thorgeirsson, Thorgeir E.; Traylor, Matthew; Treutlein, Jens; Trubetskoy, Vassily; Uitterlinden, André G.; Umbricht, Daniel; der Auwera, Sandra Van; van Hemert, Albert M.; Viktorin, Alexander; Visscher, Peter M.; Wang, Yunpeng; Webb, Bradley T.; Perlis, Roy H.; Porteous, David J.; Schaefer, Catherine; Stefansson, Kari; Tiemeier, Henning; Uher, Rudolf; Werge, Thomas; Lewis, Cathryn M.; Breen, Gerome; Børglum, Anders D.; Sullivan, Patrick F.; O’Connell, Kevin S.; Coombes, Brandon; Qiao, Zhen; Als, Thomas D.; Børte, Sigrid; Charney, Alexander W.; Drange, Ole Kristian; Gandal, Michael J.; Hagenaars, Saskia P.; Ikeda, Masashi; Kamitaki, Nolan; Krebs, Kristi; Panagiotaropoulou, Georgia; Schilder, Brian M.; Sloofman, Laura G.; Winsvold, Bendik S.; Won, Hong-Hee; Abramova, Liliya; Adorjan, Kristina; Al Eissa, Mariam; Albani, Diego; Alliey-Rodriguez, Ney; Antilla, Verneri; Antoniou, Anastasia; Baek, Ji Hyun; Bauer, Michael; Beins, Eva C.; Bergen, Sarah E.; Birner, Armin; Bøen, Erlend; Brum, Murielle; Brumpton, Ben M.; Brunkhorst-Kanaan, Nathalie; Byerley, William; Cairns, Murray; Casas, Miquel; Cervantes, Pablo; Cruceanu, Cristiana; Cuellar-Barboza, Alfredo; Cunningham, Julie; Curtis, David; Czerski, Piotr M.; Dale, Anders M.; Dalkner, Nina; David, Friederike S.; Dobbyn, Amanda L.; Douzenis, Athanassios; Elvsåshagen, Torbjørn; Ferrier, I. 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John; Rentería, Miguel E.; Stein, Murray B.; Willour, Virginia
Contributor organization: Institute for Molecular Medicine Finland
Centre of Excellence in Complex Disease Genetics
Aarno Palotie / Principal Investigator
Genomics of Neurological and Neuropsychiatric Disorders
HUS Psychiatry
Department of Public Health
Clinicum
Nuorisopsykiatria
Faculty Common Matters
Samuli Olli Ripatti / Principal Investigator
Complex Disease Genetics
Biostatistics Helsinki
Anna Keski-Rahkonen / Principal Investigator
Elisabeth Ingrid Maria Widen / Principal Investigator
Genomic Discoveries and Clinical Translation
Date: 2022-02-01
Language: eng
Number of pages: 15
Belongs to series: Biological Psychiatry
ISSN: 0006-3223
DOI: https://doi.org/10.1016/j.biopsych.2021.05.029
URI: http://hdl.handle.net/10138/338669
Abstract: Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
Subject: Genetic correlation
Genome-wide association study
Pleiotropy
Polygenicity
Suicide
Suicide attempt
3124 Neurology and psychiatry
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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