Surgical treatment of symptomatic pineal cysts without hydrocephalus-meta-analysis of the published literature

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http://hdl.handle.net/10138/340040

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Masina , R , Ansaripour , A , Benes , V , Berhouma , M , Choque-Velasquez , J , Eide , P K , Fedorko , S , Fleck , S , Hernesniemi , J , Koziarski , A , Majovsky , M , Podgorski , A , Schroeder , H , Teo , C , Unterberg , A W , Yeung , J T , Kolias , A & Santarius , T 2022 , ' Surgical treatment of symptomatic pineal cysts without hydrocephalus-meta-analysis of the published literature ' , Acta Neurochirurgica , vol. 164 , no. 1 , pp. 61-77 . https://doi.org/10.1007/s00701-021-05054-0

Title: Surgical treatment of symptomatic pineal cysts without hydrocephalus-meta-analysis of the published literature
Author: Masina, Riccardo; Ansaripour, Ali; Benes, Vladimir; Berhouma, Moncef; Choque-Velasquez, Joham; Eide, Per Kristian; Fedorko, Stepan; Fleck, Steffen; Hernesniemi, Juha; Koziarski, Andrzej; Majovsky, Martin; Podgorski, Andrzej; Schroeder, Henry; Teo, Charles; Unterberg, Andreas W.; Yeung, Jacky T.; Kolias, Angelos; Santarius, Thomas
Contributor organization: Clinicum
HUS Neurocenter
Neurokirurgian yksikkö
Department of Neurosciences
Date: 2022-01
Language: eng
Number of pages: 17
Belongs to series: Acta Neurochirurgica
ISSN: 0001-6268
DOI: https://doi.org/10.1007/s00701-021-05054-0
URI: http://hdl.handle.net/10138/340040
Abstract: Background To examine published data and assess evidence relating to safety and efficacy of surgical management of symptomatic pineal cysts without hydrocephalus (nhSPC), we performed a systematic review of the literature and meta-analysis. Methods Following the PRISMA guidelines, we searched Pubmed and SCOPUS for all reports with the query 'Pineal Cyst' AND 'Surgery' as of March 2021, without constraints on study design, publication year or status (PROSPERO_CRD:42,021,242,517). Assessment of 1537 hits identified 26 reports that met inclusion and exclusion criteria. Results All 26 input studies were either case reports or single-centre retrospective cohorts. The majority of outcome data were derived from routine physician-recorded notes. A total of 294 patients with surgically managed nhSPC were identified. Demographics: Mean age was 29 (range: 4-63) with 77% females. Mean cyst size was 15 mm (5-35). Supracerebellar-infratentorial approach was adopted in 90% of cases, occipital-transtentorial in 9%, and was not reported in 1%. Most patients were managed by cyst resection (96%), and the remainder by fenestration. Mean post-operative follow-up was 35 months (0-228). Presentation: Headache was the commonest symptom (87%), followed by visual (54%), nausea/vomit (34%) and vertigo/dizziness (31%). Other symptoms included focal neurology (25%), sleep disturbance (17%), cognitive impairment (16%), loss of consciousness (11%), gait disturbance (11%), fatigue (10%), 'psychiatric' (2%) and seizures (1%). Mean number of symptoms reported at presentation was 3 (0-9). Outcomes: Improvement rate was 93% (to minimise reporting bias only consecutive cases from cohort studies were considered, N= 280) and was independent of presentation. Predictors of better outcomes were large cyst size (OR= 5.76; 95% CI: 1.74-19.02) and resection over fenestration (OR= 12.64; 3.07-52.01). Age predicted worse outcomes (OR= 0.95; 0.91-0.99). Overall complication rate was 17% and this was independent of any patient characteristics. Complications with long-term consequences occurred in 10 cases (3.6%): visual disturbance (3), chronic incisional pain (2), sensory disturbance (1), fatigue (1), cervicalgia (1), cerebellar stroke (1) and mortality due to myocardial infarction (1). Conclusions Although the results support the role of surgery in the management of nhSPCs, they have to be interpreted with a great deal of caution as the current evidence is limited, consisting only of case reports and retrospective surgical series. Inherent to such studies are inhomogeneity and incompleteness of data, selection bias and bias related to assessment of outcome carried out by the treating surgeon in the majority of cases. Prospective studies with patient-reported and objective outcome assessment are needed to provide higher level of evidence.
Subject: Pineal
Pineal cyst
Symptomatic pineal cyst
Non-hydrocephalic symptomatic pineal cyst
Hydrocephalus
Headache
SUPERIOR COLLICULUS
CASE SERIES
MANAGEMENT
RESECTION
APOPLEXY
GLAND
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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