Cerebrospinal fluid dynamics in idiopathic intracranial hypertension : a literature review and validation of contemporary findings

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Kaipainen , A L , Martoma , E , Puustinen , T , Tervonen , J , Jyrkkänen , H K , Paterno , J J , Kotkansalo , A , Rantala , S , Vanhanen , U , Leinonen , V , Lehto , S M , Iso-Mustajärvi , M , Elomaa , A P , Qvarlander , S & Huuskonen , T J 2021 , ' Cerebrospinal fluid dynamics in idiopathic intracranial hypertension : a literature review and validation of contemporary findings ' , Acta Neurochirurgica , vol. 163 , no. 12 , pp. 3353-3368 . https://doi.org/10.1007/s00701-021-04940-x

Title: Cerebrospinal fluid dynamics in idiopathic intracranial hypertension : a literature review and validation of contemporary findings
Author: Kaipainen, Aku L.; Martoma, Erik; Puustinen, Tero; Tervonen, Joona; Jyrkkänen, Henna Kaisa; Paterno, Jussi J.; Kotkansalo, Anna; Rantala, Susanna; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M.; Iso-Mustajärvi, Matti; Elomaa, Antti Pekka; Qvarlander, Sara; Huuskonen, Terhi J.
Contributor organization: HUS Neurocenter
Clinicum
Department of Psychiatry
University of Helsinki
Date: 2021-12
Language: eng
Number of pages: 16
Belongs to series: Acta Neurochirurgica
ISSN: 0001-6268
DOI: https://doi.org/10.1007/s00701-021-04940-x
URI: http://hdl.handle.net/10138/340099
Abstract: Background: Idiopathic intracranial hypertension (IIH) is a rare disease of unknown aetiology related possibly to disturbed cerebrospinal fluid (CSF) dynamics and characterised by elevated intracranial pressure (ICP) causing optic nerve atrophy if not timely treated. We studied CSF dynamics of the IIH patients based on the available literature and our well-defined cohort. Method: A literature review was performed from PubMed between 1980 and 2020 in compliance with the PRISMA guideline. Our study includes 59 patients with clinical, demographical, neuro-ophthalmological, radiological, outcome data, and lumbar CSF pressure measurements for suspicion of IIH; 39 patients had verified IIH while 20 patients did not according to Friedman’s criteria, hence referred to as symptomatic controls. Results: The literature review yielded 19 suitable studies; 452 IIH patients and 264 controls had undergone intraventricular or lumbar CSF pressure measurements. In our study, the mean CSF pressure, pulse amplitudes, power of respiratory waves (RESP), and the pressure constant (P0) were higher in IIH than symptomatic controls (p < 0.01). The mean CSF pressure was higher in IIH patients with psychiatric comorbidity than without (p < 0.05). In IIH patients without acetazolamide treatment, the RAP index and power of slow waves were also higher (p < 0.05). IIH patients with excess CSF around the optic nerves had lower relative pulse pressure coefficient (RPPC) and RESP than those without (p < 0.05). Conclusions: Our literature review revealed increased CSF pressure, resistance to CSF outflow and sagittal sinus pressure (SSP) as key findings in IIH. Our study confirmed significantly higher lumbar CSF pressure and increased CSF pressure waves and RAP index in IIH when excluding patients with acetazolamide treatment. In overall, the findings reflect decreased craniospinal compliance and potentially depleted cerebral autoregulation resulting from the increased CSF pressure in IIH. The increased slow waves in patients without acetazolamide may indicate issues in autoregulation, while increased P0 could reflect the increased SSP.
Description: Publisher Copyright: © 2021, The Author(s).
Subject: Cerebrospinal fluid dynamics
Cerebrospinal fluid pressure measurement
Idiopathic intracranial hypertension
MECHANISM
OUTFLOW
ACETAZOLAMIDE
ELASTANCE
PSEUDOTUMOR CEREBRI
PULSE PRESSURE
RESISTANCE
BARIATRIC SURGERY
SAGITTAL SINUS
CEREBRAL-BLOOD-FLOW
3112 Neurosciences
3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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