Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart

Show full item record



Permalink

http://hdl.handle.net/10138/340114

Citation

Torregrosa-Munumer , R , Vara , E , Fernandez-Tresguerres , J A & Gredilla , R 2021 , ' Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart ' , European Journal of Nutrition , vol. 60 , no. 5 , pp. 2683-2693 . https://doi.org/10.1007/s00394-020-02457-0

Title: Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart
Author: Torregrosa-Munumer, Ruben; Vara, Elena; Fernandez-Tresguerres, Jesus Angel; Gredilla, Ricardo
Contributor organization: STEMM - Stem Cells and Metabolism Research Program
Research Programs Unit
Date: 2021-08
Language: eng
Number of pages: 11
Belongs to series: European Journal of Nutrition
ISSN: 1436-6207
DOI: https://doi.org/10.1007/s00394-020-02457-0
URI: http://hdl.handle.net/10138/340114
Abstract: Purpose Aging is known to play a critical role in the etiopathogenesis of several diseases. Among them, cardiovascular disorders are especially relevant since they are becoming the first cause of death in western countries. Resveratrol is a polyphenolic compound that has been shown to exert beneficial effects at different levels, including neuronal and cardiovascular protection. Those effects of resveratrol are related, at least in part, to its antioxidant and anti-inflammatory properties. In the current investigation we were interested in exploring whether the positive effects of resveratrol at cardiac level were taking place even when the supplementation started in already old animals. Methods Old male rats were supplemented with resveratrol during 10 weeks. Using RT-PCR, we analyzed the effects of resveratrol supplementation on the expression of different genes related to inflammation, oxidative stress and apoptosis in rat heart. Results Resveratrol reverted age-related changes in inflammatory, oxidative and apoptotic markers in the rat heart. Among others, the expression of two major inflammatory markers, INF-gamma and TNF-alpha and two oxidative markers, heme oxygenase-1 and nitric oxide synthase, were increased with aging, and resveratrol supplementation reduced the level of some of these to those observed in the heart of young animals. Moreover, age-related changes in apoptotic markers in rat heart tend to be also reverted by resveratrol treatment. Conclusion Our results suggest that resveratrol might exert beneficial effects as an anti-aging compound to revert age-related changes in cardiac function.
Subject: Resveratrol
Aging
Heart
Inflammation
Oxidation
Apoptosis
NITRIC-OXIDE SYNTHASE
TERM CALORIC RESTRICTION
FACTOR-KAPPA-B
ENDOTHELIAL DYSFUNCTION
CARDIOVASCULAR HEALTH
CARDIAC DYSFUNCTION
SIRT1 ACTIVATION
GENE-EXPRESSION
CELL-DEATH
STRESS
3143 Nutrition
Peer reviewed: Yes
Rights: other
Usage restriction: openAccess
Self-archived version: acceptedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
Resveratol.pdf 4.871Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record