Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study

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Drummen , M , Adam , T C , Macdonald , I A , Jalo , E , Larssen , T M , Martinez , J A , Handjiev-Darlenska , T , Brand-Miller , J , Poppitt , S D , Stratton , G , Pietiläinen , K , Taylor , M A , Navas-Carretero , S , Handjiev , S , Muirhead , R , Silvestre , M P , Swindell , N , Huttunen-Lenz , M , Schlicht , W , Lam , T , Sundvall , J , Råman , L , Feskens , E , Tremblay , A , Raben , A & Westerterp-Plantenga , M S 2021 , ' Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study ' , American Journal of Clinical Nutrition , vol. 114 , no. 5 , pp. 1847-1858 . https://doi.org/10.1093/ajcn/nqab247

Title: Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study
Author: Drummen, Mathijs; Adam, Tanja C.; Macdonald, Ian A.; Jalo, Elli; Larssen, Thomas M.; Martinez, J. Alfredo; Handjiev-Darlenska, Teodora; Brand-Miller, Jennie; Poppitt, Sally D.; Stratton, Gareth; Pietiläinen, Kirsi; Taylor, Moira A.; Navas-Carretero, Santiago; Handjiev, Svetoslav; Muirhead, Roslyn; Silvestre, Marta P.; Swindell, Nils; Huttunen-Lenz, Maija; Schlicht, Wolfgang; Lam, Tony; Sundvall, Jouko; Råman, Laura; Feskens, Edith; Tremblay, Angelo; Raben, Anne; Westerterp-Plantenga, Margriet S.
Contributor organization: Department of Food and Nutrition
HUS Abdominal Center
Department of Medicine
Clinicum
Date: 2021-11
Language: eng
Number of pages: 12
Belongs to series: American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: https://doi.org/10.1093/ajcn/nqab247
URI: http://hdl.handle.net/10138/340132
Abstract: Background: Observed associations of high-protein diets with changes in insulin resistance are inconclusive. Objectives: We aimed to assess associations of changes in both reported and estimated protein (P-Rep; P-Est) and energy intake (EIRep; EIEST) with changes in HOMA-IR, glycated hemoglobin (HbA1c), and BMI (in kg/m(2)), in 1822 decreasing to 833 adults (week 156) with overweight and prediabetes, during the 3-y PREVIEW (PREVention of diabetes through lifestyle intervention and population studies In Europe and around the World) study on weight-loss maintenance. Eating behavior and measurement errors (MEs) of dietary intake were assessed. Thus, observational post hoc analyses were applied. Methods: Associations of changes in EIEst, EIRep, P-Est, and P-Rep with changes in HOMA-1R, HbA1c, and BMI were determined by linear mixed-model analysis in 2 arms [high-protein-low-glycemicindex (GI) diet and moderate-protein-moderate-GI diet] of the PREVIEW study. EI Est was derived from energy requirement: total energy expenditure = basal metabolic rate x physical activity level; P-Est from urinary nitrogen, and urea. MEs were calculated as [EIEst - EIRep)/EIEst] x 100% and [(P-Rep- P-Est)/P-Est] x 100%. Eating behavior was determined using the Three Factor Eating Questionnaire, examining cognitive dietary restraint, disinhibition, and hunger. Results: Increases in P-Est and P-Rep and decreases in EIEst and EIRep were associated with decreases in BMI, but not independently with decreases in HOMA-IR. Increases in P-Est and P-Rep were associated with decreases in HbA1c. P-Rep and EIRep showed larger changes and stronger associations than P-Est and EIEst. Mean +/- SD MEs of EIRep and P-Rep were 38% +/- 9% and 14% +/- 4%, respectively: ME changes in EIRep and En% P-Rep were positively associated with changes in BMI and cognitive dietary restraint and inversely with disinhibition and hunger. Conclusions: During weight-loss maintenance in adults with prediabetes, increase in protein intake and decrease in energy intake were not associated with decrease in HOMA-IR beyond associations with decrease in BMI. Increases in P-Est and P-Rep were associated with decrease in HbA1c.
Subject: 3141 Health care science
3142 Public health care science, environmental and occupational health
3143 Nutrition
416 Food Science
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion


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