Prognostic significance of esterase gene expression in multiple myeloma

Show full item record



Permalink

http://hdl.handle.net/10138/340172

Citation

Kumari , R , Majumder , M M , Lievonen , J , Silvennoinen , R , Anttila , P , Nupponen , N N , Lehmann , F & Heckman , C A 2021 , ' Prognostic significance of esterase gene expression in multiple myeloma ' , British Journal of Cancer , vol. 124 , no. 8 , pp. 1428-1436 . https://doi.org/10.1038/s41416-020-01237-1

Title: Prognostic significance of esterase gene expression in multiple myeloma
Author: Kumari, Romika; Majumder, Muntasir Mamun; Lievonen, Juha; Silvennoinen, Raija; Anttila, Pekka; Nupponen, Nina N.; Lehmann, Fredrik; Heckman, Caroline A.
Contributor organization: Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
Digital Precision Cancer Medicine (iCAN)
Hematologian yksikkö
HUS Comprehensive Cancer Center
Department of Oncology
University of Helsinki
Date: 2021-04-12
Language: eng
Number of pages: 9
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
DOI: https://doi.org/10.1038/s41416-020-01237-1
URI: http://hdl.handle.net/10138/340172
Abstract: Background Esterase enzymes differ in substrate specificity and biological function and may display dysregulated expression in cancer. This study evaluated the biological significance of esterase expression in multiple myeloma (MM). Methods For gene expression profiling and evaluation of genomic variants in the Institute for Molecular Medicine Finland (FIMM) cohort, bone marrow aspirates were obtained from patients with newly diagnosed MM (NDMM) or relapsed/refractory MM (RRMM). CD138+ plasma cells were enriched and used for RNA sequencing and analysis, and to evaluate genomic variation. The Multiple Myeloma Research Foundation (MMRF) Relating Clinical Outcomes in MM to Personal Assessment of Genetic Profile (CoMMpass) dataset was used for validation of the findings from FIMM. Results MM patients (NDMM, n = 56; RRMM, n = 78) provided 171 bone marrow aspirates (NDMM, n = 56; RRMM, n = 115). Specific esterases exhibited relatively high or low expression in MM, and expression of specific esterases (UCHL5, SIAE, ESD, PAFAH1B3, PNPLA4 and PON1) was significantly altered on progression from NDMM to RRMM. High expression of OVCA2, PAFAH1B3, SIAE and USP4, and low expression of PCED1B, were identified as poor prognostic markers (P <0.05). The MMRF CoMMpass dataset provided validation that higher expression of PAFAH1B3 and SIAE, and lower expression of PCED1B, were associated with poor prognosis. Conclusions Esterase gene expression levels change as patients progress from NDMM to RRMM. High expression of OVCA2, PAFAH1B3, USP4 and SIAE, and low expression of PCED1B, are poor prognostic markers in MM, suggesting a role for these esterases in myeloma biology.
Subject: 3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41416_020_01237_1.pdf 1.195Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record