Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

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Oroojalian , F , Beygi , M , Baradaran , B , Mokhtarzadeh , A & Shahbazi , M-A 2021 , ' Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy ' , Small , vol. 17 , no. 12 , 2006484 .

Title: Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy
Author: Oroojalian, Fatemeh; Beygi, Mohammad; Baradaran, Behzad; Mokhtarzadeh, Ahad; Shahbazi, Mohammad-Ali
Contributor organization: Nanomedicines and Biomedical Engineering
Division of Pharmaceutical Chemistry and Technology
Drug Research Program
Date: 2021-03
Language: eng
Number of pages: 33
Belongs to series: Small
ISSN: 1613-6810
Abstract: Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes to clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, and rapid clearance from the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed to solve these issues. For example, macrophage or neutrophil cell membrane coated NPs are developed with the ability to interact with tumor tissue to suppress cancer progression and metastasis. The functionality of these particles largely depends on the surface proteins of the immune cells and their preserved function during membrane extraction and coating process on the NPs. Proteins on the outer surface of immune cells can render a wide range of activities to the NPs, including prolonged blood circulation, remarkable competency in recognizing antigens for enhanced targeting, better cellular interactions, gradual drug release, and reduced toxicity in vivo. In this review, nano-based systems coated with immune cells-derived membranous layers, their detailed production process, and the applicability of these biomimetic systems in cancer treatment are discussed. In addition, future perspectives and challenges for their clinical translation are also presented.
Subject: biomimetics
immune cell membranes
T cells
116 Chemical sciences
221 Nano-technology
318 Medical biotechnology
317 Pharmacy
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion

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