Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Show simple item record Oroojalian, Fatemeh Beygi, Mohammad Baradaran, Behzad Mokhtarzadeh, Ahad Shahbazi, Mohammad-Ali 2022-02-11T23:22:27Z 2022-02-12T03:45:19Z 2021-03
dc.identifier.citation Oroojalian , F , Beygi , M , Baradaran , B , Mokhtarzadeh , A & Shahbazi , M-A 2021 , ' Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy ' , Small , vol. 17 , no. 12 , 2006484 .
dc.identifier.other PURE: 161092846
dc.identifier.other PURE UUID: 09167573-312d-4645-92ee-db1492633103
dc.identifier.other WOS: 000617308200001
dc.description.abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes to clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, and rapid clearance from the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed to solve these issues. For example, macrophage or neutrophil cell membrane coated NPs are developed with the ability to interact with tumor tissue to suppress cancer progression and metastasis. The functionality of these particles largely depends on the surface proteins of the immune cells and their preserved function during membrane extraction and coating process on the NPs. Proteins on the outer surface of immune cells can render a wide range of activities to the NPs, including prolonged blood circulation, remarkable competency in recognizing antigens for enhanced targeting, better cellular interactions, gradual drug release, and reduced toxicity in vivo. In this review, nano-based systems coated with immune cells-derived membranous layers, their detailed production process, and the applicability of these biomimetic systems in cancer treatment are discussed. In addition, future perspectives and challenges for their clinical translation are also presented. en
dc.format.extent 33
dc.language.iso eng
dc.relation.ispartof Small
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject biomimetics
dc.subject immune cell membranes
dc.subject macrophages
dc.subject nanoparticles
dc.subject neutrophils
dc.subject T cells
dc.subject 116 Chemical sciences
dc.subject 221 Nano-technology
dc.subject 318 Medical biotechnology
dc.subject 317 Pharmacy
dc.title Immune Cell Membrane-Coated Biomimetic Nanoparticles for Targeted Cancer Therapy en
dc.type Review Article
dc.contributor.organization Nanomedicines and Biomedical Engineering
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Drug Research Program
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1613-6810
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Immune_cell_membrane_Revised.pdf 3.895Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record