Maternal autoimmune disease is not associated with cancer in the offspring

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Seppälä , L K , Madanat-Harjuoja , L-M , Troisi , R , Sampson , J N , Leinonen , M K & Vettenranta , K 2021 , ' Maternal autoimmune disease is not associated with cancer in the offspring ' , Acta Paediatrica , vol. 110 , no. 7 , pp. 2259-2266 .

Title: Maternal autoimmune disease is not associated with cancer in the offspring
Author: Seppälä, Laura K.; Madanat-Harjuoja, Laura-Maria; Troisi, Rebecca; Sampson, Joshua N.; Leinonen, Maarit K.; Vettenranta, Kim
Contributor organization: Children's Hospital
University of Helsinki
Helsinki University Hospital Area
HUS Children and Adolescents
Lastentautien yksikkö
Date: 2021-07
Language: eng
Number of pages: 8
Belongs to series: Acta Paediatrica
ISSN: 0803-5253
Abstract: Aim Autoimmune disease and its medication are associated with increased cancer risk in adults, but it is unknown whether maternal autoimmune disease and/or medication use in pregnancy are associated with increased cancer risk in offspring. Methods In this case-control study, we identified all patients under 20 years of age with their first cancer diagnosis in 1996-2014 from the Finnish Cancer Registry (n = 2029) and 1:5 population-based controls (n = 10,103) from the Medical Birth Register. We obtained information on maternal autoimmune disease and its medication from the relevant Finnish registries and used conditional logistic regression to analyse the risk of offspring cancer after maternal autoimmune disease exposure. Results The odds ratio (OR) for cancer in offspring following maternal autoimmune exposure was 0.76 (95% confidence interval [CI] 0.47-1.23). Individual ORs for inflammatory bowel and connective tissue diseases were 1.08 (95% CI 0.56-2.01) and 0.50 (95% CI 0.23-1.08), respectively. The OR for maternal autoimmune medication was 0.95 (95% CI 0.80-1.14) overall and similar by drug subtype. There was an increased risk with medication in late pregnancy but the ORs were unstable owing to small numbers. Conclusion Our study does not support an increased cancer risk among offspring of women with autoimmune disease or its medication during pregnancy.
Subject: antenatal exposure
childhood cancer risk
maternal autoimmune disease
maternal medication
based study
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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