Maternal autoimmune disease is not associated with cancer in the offspring

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dc.contributor.author Seppälä, Laura K.
dc.contributor.author Madanat-Harjuoja, Laura-Maria
dc.contributor.author Troisi, Rebecca
dc.contributor.author Sampson, Joshua N.
dc.contributor.author Leinonen, Maarit K.
dc.contributor.author Vettenranta, Kim
dc.date.accessioned 2022-02-16T07:41:01Z
dc.date.available 2022-02-16T07:41:01Z
dc.date.issued 2021-07
dc.identifier.citation Seppälä , L K , Madanat-Harjuoja , L-M , Troisi , R , Sampson , J N , Leinonen , M K & Vettenranta , K 2021 , ' Maternal autoimmune disease is not associated with cancer in the offspring ' , Acta Paediatrica , vol. 110 , no. 7 , pp. 2259-2266 . https://doi.org/10.1111/apa.15821
dc.identifier.other PURE: 164213864
dc.identifier.other PURE UUID: 54fcec44-183f-4efc-9983-8a350950eb76
dc.identifier.other WOS: 000626316200001
dc.identifier.uri http://hdl.handle.net/10138/340325
dc.description.abstract Aim Autoimmune disease and its medication are associated with increased cancer risk in adults, but it is unknown whether maternal autoimmune disease and/or medication use in pregnancy are associated with increased cancer risk in offspring. Methods In this case-control study, we identified all patients under 20 years of age with their first cancer diagnosis in 1996-2014 from the Finnish Cancer Registry (n = 2029) and 1:5 population-based controls (n = 10,103) from the Medical Birth Register. We obtained information on maternal autoimmune disease and its medication from the relevant Finnish registries and used conditional logistic regression to analyse the risk of offspring cancer after maternal autoimmune disease exposure. Results The odds ratio (OR) for cancer in offspring following maternal autoimmune exposure was 0.76 (95% confidence interval [CI] 0.47-1.23). Individual ORs for inflammatory bowel and connective tissue diseases were 1.08 (95% CI 0.56-2.01) and 0.50 (95% CI 0.23-1.08), respectively. The OR for maternal autoimmune medication was 0.95 (95% CI 0.80-1.14) overall and similar by drug subtype. There was an increased risk with medication in late pregnancy but the ORs were unstable owing to small numbers. Conclusion Our study does not support an increased cancer risk among offspring of women with autoimmune disease or its medication during pregnancy. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Acta Paediatrica
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject antenatal exposure
dc.subject childhood cancer risk
dc.subject maternal autoimmune disease
dc.subject maternal medication
dc.subject registry&#8208
dc.subject based study
dc.subject 3123 Gynaecology and paediatrics
dc.title Maternal autoimmune disease is not associated with cancer in the offspring en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Lastentautien yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/apa.15821
dc.relation.issn 0803-5253
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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