The impact of parental risk factors on the risk of stroke in type 1 diabetes

Näytä kaikki kuvailutiedot



Pysyväisosoite

http://hdl.handle.net/10138/340330

Lähdeviite

FinnDiane Study Grp , Ylinen , A , Hägg-Holmberg , S , Eriksson , M I , Forsblom , C , Harjutsalo , V , Putaala , J , Groop , P-H & Thorn , L M 2021 , ' The impact of parental risk factors on the risk of stroke in type 1 diabetes ' , Acta Diabetologica , vol. 58 , no. 7 , pp. 911-917 . https://doi.org/10.1007/s00592-021-01694-x

Julkaisun nimi: The impact of parental risk factors on the risk of stroke in type 1 diabetes
Tekijä: FinnDiane Study Grp; Ylinen, Anni; Hägg-Holmberg, Stefanie; Eriksson, Marika I.; Forsblom, Carol; Harjutsalo, Valma; Putaala, Jukka; Groop, Per-Henrik; Thorn, Lena M.
Tekijän organisaatio: Nefrologian yksikkö
University of Helsinki
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Research Programs Unit
Institute for Molecular Medicine Finland
Clinicum
HUS Neurocenter
HUS Abdominal Center
Department of Medicine
Per Henrik Groop / Principal Investigator
Department of General Practice and Primary Health Care
Päiväys: 2021-07
Kieli: eng
Sivumäärä: 7
Kuuluu julkaisusarjaan: Acta Diabetologica
ISSN: 0940-5429
DOI-tunniste: https://doi.org/10.1007/s00592-021-01694-x
URI: http://hdl.handle.net/10138/340330
Tiivistelmä: Background Individuals with type 1 diabetes have a markedly increased risk of stroke. In the general population, genetic predisposition has been linked to increased risk of stroke, but this has not been assessed in type 1 diabetes. Our aim was, therefore, to study how parental risk factors affect the risk of stroke in individuals with type 1 diabetes. Methods This study represents an observational follow-up of 4011 individuals from the Finnish Diabetic Nephropathy Study, mean age at baseline 37.6 +/- 11.9 years. All strokes during follow-up were verified from medical records or death certificates. The strokes were classified as either ischemic or hemorrhagic. All individuals filled out questionnaires concerning their parents' medical history of hypertension, diabetes, stroke, and/or myocardial infarction. Results During a median follow-up of 12.4 (10.9-14.2) years, 188 individuals (4.6%) were diagnosed with their first ever stroke; 134 were ischemic and 54 hemorrhagic. In Cox regression analysis, a history of maternal stroke increased the risk of hemorrhagic stroke, hazard ratio 2.86 (95% confidence interval 1.27-6.44, p = 0.011) after adjustment for sex, age, BMI, retinal photocoagulation, and diabetic kidney disease. There was, however, no association between maternal stroke and ischemic stroke. No other associations between parental risk factors and ischemic or hemorrhagic stroke were observed. Conclusion A history of maternal stroke increases the risk of hemorrhagic stroke in individuals with type 1 diabetes. Other parental risk factors seem to have limited impact on the risk of stroke.
Avainsanat: Parental risk factors
Cardiovascular complications
Stroke
Hemorrhagic stroke
Ischemic stroke
Type 1 diabetes
3121 General medicine, internal medicine and other clinical medicine
Vertaisarvioitu: Kyllä
Tekijänoikeustiedot: cc_by
Pääsyrajoitteet: openAccess
Rinnakkaistallennettu versio: publishedVersion


Tiedostot

Latausmäärä yhteensä: Ladataan...

Tiedosto(t) Koko Formaatti Näytä
Ylinen2021_Arti ... tOfParentalRiskFactors.pdf 514.0KB PDF Avaa tiedosto

Viite kuuluu kokoelmiin:

Näytä kaikki kuvailutiedot