The impact of parental risk factors on the risk of stroke in type 1 diabetes

Show simple item record FinnDiane Study Grp Ylinen, Anni Hägg-Holmberg, Stefanie Eriksson, Marika I. Forsblom, Carol Harjutsalo, Valma Putaala, Jukka Groop, Per-Henrik Thorn, Lena M. 2022-02-16T08:00:01Z 2022-02-16T08:00:01Z 2021-07
dc.identifier.citation FinnDiane Study Grp , Ylinen , A , Hägg-Holmberg , S , Eriksson , M I , Forsblom , C , Harjutsalo , V , Putaala , J , Groop , P-H & Thorn , L M 2021 , ' The impact of parental risk factors on the risk of stroke in type 1 diabetes ' , Acta Diabetologica , vol. 58 , no. 7 , pp. 911-917 .
dc.identifier.other PURE: 162980424
dc.identifier.other PURE UUID: ed0bcece-4816-459e-a66e-4d4dd156f001
dc.identifier.other WOS: 000629195000004
dc.identifier.other ORCID: /0000-0003-3999-0390/work/108463955
dc.description.abstract Background Individuals with type 1 diabetes have a markedly increased risk of stroke. In the general population, genetic predisposition has been linked to increased risk of stroke, but this has not been assessed in type 1 diabetes. Our aim was, therefore, to study how parental risk factors affect the risk of stroke in individuals with type 1 diabetes. Methods This study represents an observational follow-up of 4011 individuals from the Finnish Diabetic Nephropathy Study, mean age at baseline 37.6 +/- 11.9 years. All strokes during follow-up were verified from medical records or death certificates. The strokes were classified as either ischemic or hemorrhagic. All individuals filled out questionnaires concerning their parents' medical history of hypertension, diabetes, stroke, and/or myocardial infarction. Results During a median follow-up of 12.4 (10.9-14.2) years, 188 individuals (4.6%) were diagnosed with their first ever stroke; 134 were ischemic and 54 hemorrhagic. In Cox regression analysis, a history of maternal stroke increased the risk of hemorrhagic stroke, hazard ratio 2.86 (95% confidence interval 1.27-6.44, p = 0.011) after adjustment for sex, age, BMI, retinal photocoagulation, and diabetic kidney disease. There was, however, no association between maternal stroke and ischemic stroke. No other associations between parental risk factors and ischemic or hemorrhagic stroke were observed. Conclusion A history of maternal stroke increases the risk of hemorrhagic stroke in individuals with type 1 diabetes. Other parental risk factors seem to have limited impact on the risk of stroke. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Acta Diabetologica
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Parental risk factors
dc.subject Cardiovascular complications
dc.subject Stroke
dc.subject Hemorrhagic stroke
dc.subject Ischemic stroke
dc.subject Type 1 diabetes
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title The impact of parental risk factors on the risk of stroke in type 1 diabetes en
dc.type Article
dc.contributor.organization Nefrologian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Faculty of Medicine
dc.contributor.organization Research Programs Unit
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Clinicum
dc.contributor.organization HUS Neurocenter
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Department of Medicine
dc.contributor.organization Per Henrik Groop / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0940-5429
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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