Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes

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FinnDiane Study Grp , Inkeri , J , Tynjälä , A , Forsblom , C , Liebkind , R , Tatlisumak , T , Thorn , L M , Groop , P-H , Shams , S , Putaala , J , Martola , J & Gordin , D 2021 , ' Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes ' , Acta Diabetologica , vol. 58 , no. 7 , pp. 929-937 . https://doi.org/10.1007/s00592-021-01678-x

Title: Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes
Author: FinnDiane Study Grp; Inkeri, Jussi; Tynjälä, Anniina; Forsblom, Carol; Liebkind, Ron; Tatlisumak, Turgut; Thorn, Lena M.; Groop, Per-Henrik; Shams, Sara; Putaala, Jukka; Martola, Juha; Gordin, Daniel
Contributor organization: HUS Medical Imaging Center
University of Helsinki
Helsinki University Hospital Area
HUS Abdominal Center
Nefrologian yksikkö
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Institute for Molecular Medicine Finland
HUS Neurocenter
Neurologian yksikkö
Department of Neurosciences
Department of General Practice and Primary Health Care
Department of Medicine
Per Henrik Groop / Principal Investigator
Clinicum
Department of Diagnostics and Therapeutics
Date: 2021-07
Language: eng
Number of pages: 9
Belongs to series: Acta Diabetologica
ISSN: 0940-5429
DOI: https://doi.org/10.1007/s00592-021-01678-x
URI: http://hdl.handle.net/10138/340332
Abstract: Aims To determine if arterial functional and structural changes are associated with underlying cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes. Methods We enrolled 186 individuals (47.8% men; median age 40.0, IQR 33.0-45.0 years) with type 1 diabetes (median diabetes duration of 21.6, IQR 18.2-30.3 years), and 30 age- and sex-matched healthy controls, as part of the Finnish Diabetic Nephropathy (FinnDiane) Study. All individuals underwent a biochemical work-up, brain magnetic resonance imaging (MRI), ultrasound of the common carotid arteries and arterial tonometry. Arterial structural and functional parameters were assessed by carotid intima-media thickness (CIMT), pulse wave velocity and augmentation index. Results Cerebral microbleeds (CMBs) were present in 23.7% and white matter hyperintensities (WMHs) in 16.7% of individuals with type 1 diabetes. Those with type 1 diabetes and CMBs had higher median (IQR) CIMT 583 (525 - 663) mu m than those without 556 (502 - 607) mu m, p = 0.016). Higher CIMT was associated with the presence of CMBs (p = 0.046) independent of age, eGFR, ApoB, systolic blood pressure, albuminuria, history of retinal photocoagulation and HbA(1c). Arterial stiffness and CIMT were increased in individuals with type 1 diabetes and WMHs compared to those without; however, these results were not independent of cardiovascular risk factors. Conclusions Structural, but not functional, arterial changes are associated with underlying CMBs in asymptomatic individuals with type 1 diabetes.
Subject: Carotid intima-media thickness
Arterial tonometry
Cerebral microbleed
Magnetic resonance imaging
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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