Could Nanotheranostics be the Answer to the Coronavirus Crisis?

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http://hdl.handle.net/10138/340336

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Abdelrehiem , D A M , Assad , M A , Sironen , T & Elbahri , M 2021 , ' Could Nanotheranostics be the Answer to the Coronavirus Crisis? ' , Global Challenges , vol. 5 , no. 6 , 2000112 . https://doi.org/10.1002/gch2.202000112

Title: Could Nanotheranostics be the Answer to the Coronavirus Crisis?
Author: Abdelrehiem, Dina Ahmed Mosselhy; Assad, Mhd Adel; Sironen, Tarja; Elbahri, Mady
Contributor organization: Department of Virology
Helsinki One Health (HOH)
Viral Zoonosis Research Unit
Emerging Infections Research Group
Date: 2021-06
Language: eng
Number of pages: 13
Belongs to series: Global Challenges
ISSN: 2056-6646
DOI: https://doi.org/10.1002/gch2.202000112
URI: http://hdl.handle.net/10138/340336
Abstract: The COVID-19 pandemic is expanding worldwide. This pandemic associated with COVID-19 placed the spotlight on how bacterial (e.g., methicillin-resistant Staphylococcus aureus) co-infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and rapidly diagnose COVID-19 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely "superhydrophobic self-disinfecting electrospun facemasks/fabrics (SSEF)." SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and "top-five suggestions" for containing COVID-19 are offered, including: i) preventive appraisals-avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics-highly recommending nanodiagnostics, detecting COVID-19 within 10 min. iii) Therapeutics-expanding nanotherapeutics to treat COVID-19 and bacterial co-infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way.
Subject: 3121 General medicine, internal medicine and other clinical medicine
anti-coronavirus
appraisals
coronavirus
electrospun facemasks
nanodiagnostics
nanoparticles
PNEUMONIA
SILVER NANOPARTICLES
QUANTUM DOTS
COVID-19
INHIBITION
INFECTION
STAPHYLOCOCCUS-AUREUS
EPIDEMIOLOGY
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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