Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans

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Simons , P I H G , Valkenburg , O , Telgenkamp , I , van der Waaij , K M , de Groot , D M , Veeraiah , P , Bons , J A P , Taskinen , M-R , Boren , J , Schrauwen , P , Rutten , J H W , Cassiman , D , Schalkwijk , C G , Stehouwer , C D A , Schrauwen-Hinderling , V B , Hodson , L & Brouwers , M C G J 2021 , ' Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans ' , Clinical Endocrinology , vol. 95 , no. 1 , pp. 101-106 .

Title: Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans
Author: Simons, Pomme I. H. G.; Valkenburg, Olivier; Telgenkamp, Ine; van der Waaij, Koen M.; de Groot, David M.; Veeraiah, Pandichelvam; Bons, Judith A. P.; Taskinen, Marja-Riitta; Boren, Jan; Schrauwen, Patrick; Rutten, Joost H. W.; Cassiman, David; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Schrauwen-Hinderling, Vera B.; Hodson, Leanne; Brouwers, Martijn C. G. J.
Contributor organization: Clinicum
Marja-Riitta Taskinen Research Group
HUS Heart and Lung Center
CAMM - Research Program for Clinical and Molecular Metabolism
Date: 2021-07
Language: eng
Number of pages: 6
Belongs to series: Clinical Endocrinology
ISSN: 0300-0664
Abstract: Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans. Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex. Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%). Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin. Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.
Subject: de novo lipogenesis
liver fat
alcoholic fatty liver disease
polycystic ovary syndrome
sex hormone binding globulin
stable isotopes
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: acceptedVersion

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