Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study

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http://hdl.handle.net/10138/340345

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Peltomaa , A I , Raittinen , P , Talala , K , Taari , K , Tammela , T L J , Auvinen , A & Murtola , T J 2021 , ' Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study ' , Prostate Cancer and Prostatic Diseases , vol. 24 , no. 3 , pp. 917-924 . https://doi.org/10.1038/s41391-021-00351-2

Title: Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study
Author: Peltomaa, A. I.; Raittinen, P.; Talala, K.; Taari, K.; Tammela, T. L. J.; Auvinen, A.; Murtola, T. J.
Contributor organization: HUS Abdominal Center
Clinicum
Urologian yksikkö
Department of Surgery
University of Helsinki
Helsinki University Hospital Area
Date: 2021-09
Language: eng
Number of pages: 8
Belongs to series: Prostate Cancer and Prostatic Diseases
ISSN: 1365-7852
DOI: https://doi.org/10.1038/s41391-021-00351-2
URI: http://hdl.handle.net/10138/340345
Abstract: Purpose Statins' cholesterol-lowering efficacy is well-known. Recent epidemiological studies have found that inhibition of cholesterol synthesis may have beneficial effects on prostate cancer (PCa) patients, especially patients treated with androgen deprivation therapy (ADT). We evaluated statins' effect on prostate cancer prognosis among patients treated with ADT. Materials and methods Our study population consisted of 8253 PCa patients detected among the study population of the Finnish randomized study of screening for prostate cancer. These were limited to 4428 men who initiated ADT during the follow-up. Cox proportional regression model adjusted for tumor clinical characteristics and comorbidities was used to estimate hazard ratios for risk of PSA relapse after ADT initiation and prostate cancer death. Results During the median follow-up of 6.3 years after the ADT initiation, there were 834 PCa deaths and 1565 PSA relapses in a study cohort. Statin use after ADT was associated with a decreased risk of PSA relapse (HR 0.73, 95% CI 0.65-0.82) and prostate cancer death (HR 0.82; 95% CI 0.69-0.96). In contrast, statin use defined with a one-year lag (HR 0.89, 95% CI 0.76-1.04), statin use before ADT initiation (HR 1.12, 95% CI 0.96-1.31), and use in the first year on ADT (HR 1.02, 95% CI 0.85-1.24) were not associated with prostate cancer death, without dose dependency. Conclusion Statin use after initiation of ADT, but not before, was associated with improved prostate cancer prognosis.
Subject: 3122 Cancers
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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