An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes

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http://hdl.handle.net/10138/340358

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Kratochwil , C , Kautt , A F , Nater , A , Härer , A , Liang , Y , Henning , F & Meyer , A 2022 , ' An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes ' , Nature Communications , vol. 13 , no. 1 , 296 . https://doi.org/10.1038/s41467-021-27685-8

Title: An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes
Author: Kratochwil, Claudius; Kautt, Andreas F.; Nater, Alexander; Härer, Andreas; Liang, Yipeng; Henning, Frederico; Meyer, Axel
Contributor organization: Integrative Evolutionary Biology
Institute of Biotechnology
Date: 2022-01-13
Language: eng
Number of pages: 8
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-021-27685-8
URI: http://hdl.handle.net/10138/340358
Abstract: Polymorphisms have fascinated biologists for a long time, but their genetic underpinnings often remain elusive. Here, we aim to uncover the genetic basis of the gold/dark polymorphism that is eponymous of Midas cichlid fish (Amphilophus spp.) adaptive radiations in Nicaraguan crater lakes. While most Midas cichlids are of the melanic “dark morph”, about 10% of individuals lose their melanic pigmentation during their ontogeny and transition into a conspicuous “gold morph”. Using a new haplotype-resolved long-read assembly we discover an 8.2 kb, transposon-derived inverted repeat in an intron of an undescribed gene, which we term goldentouch in reference to the Greek myth of King Midas. The gene goldentouch is differentially expressed between morphs, presumably due to structural implications of inverted repeats in both DNA and/or RNA (cruciform and hairpin formation). The near-perfect association of the insertion with the phenotype across independent populations suggests that it likely underlies this trans-specific, stable polymorphism.
Subject: ADHESION
EVOLUTION
MORPHS
1181 Ecology, evolutionary biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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