The impact of susceptibility correction on diffusion metrics in adolescents

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PIPARI Study Grp , Lahti , K , Parkkola , R , Jääsaari , P , Haataja , L & Saunavaara , V 2021 , ' The impact of susceptibility correction on diffusion metrics in adolescents ' , Pediatric Radiology , vol. 51 , no. 8 , pp. 1471-1480 . https://doi.org/10.1007/s00247-021-05000-3

Title: The impact of susceptibility correction on diffusion metrics in adolescents
Author: PIPARI Study Grp; Lahti, Katri; Parkkola, Riitta; Jääsaari, Päivi; Haataja, Leena; Saunavaara, Virva
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Helsinki University Hospital Area
Date: 2021-07
Language: eng
Number of pages: 10
Belongs to series: Pediatric Radiology
ISSN: 0301-0449
DOI: https://doi.org/10.1007/s00247-021-05000-3
URI: http://hdl.handle.net/10138/340363
Abstract: Background Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values. Objective To explore the impact of susceptibility correction on diffusion metrics. Materials and methods A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally. Results Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract. Conclusion This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
Subject: Adolescents
Brain
Diffusion tensor imaging
Magnetic resonance imaging
Susceptibility correction
Tractography
ECHO-PLANAR IMAGES
WHITE-MATTER
MRI TRACTOGRAPHY
DISTORTION
ARTIFACTS
CONNECTIVITY
MOTION
CORTEX
3123 Gynaecology and paediatrics
3126 Surgery, anesthesiology, intensive care, radiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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