Sporulation Strategies and Potential Role of the Exosporium in Survival and Persistence of Clostridium botulinum

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Portinha , I M , Douillard , F P , Korkeala , H & Lindstrom , M 2022 , ' Sporulation Strategies and Potential Role of the Exosporium in Survival and Persistence of Clostridium botulinum ' , International Journal of Molecular Sciences , vol. 23 , no. 2 , 754 . https://doi.org/10.3390/ijms23020754

Title: Sporulation Strategies and Potential Role of the Exosporium in Survival and Persistence of Clostridium botulinum
Author: Portinha, Ines M.; Douillard, Francois P.; Korkeala, Hannu; Lindstrom, Miia
Contributor organization: Food Hygiene and Environmental Health
Departments of Faculty of Veterinary Medicine
Helsinki One Health (HOH)
Date: 2022-01
Language: eng
Number of pages: 17
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms23020754
URI: http://hdl.handle.net/10138/340405
Abstract: Clostridium botulinum produces the botulinum neurotoxin that causes botulism, a rare but potentially lethal paralysis. Endospores play an important role in the survival, transmission, and pathogenesis of C. botulinum. C. botulinum strains are very diverse, both genetically and ecologically. Group I strains are terrestrial, mesophilic, and produce highly heat-resistant spores, while Group II strains can be terrestrial (type B) or aquatic (type E) and are generally psychrotrophic and produce spores of moderate heat resistance. Group III strains are either terrestrial or aquatic, mesophilic or slightly thermophilic, and the heat resistance properties of their spores are poorly characterized. Here, we analyzed the sporulation dynamics in population, spore morphology, and other spore properties of 10 C. botulinum strains belonging to Groups I-III. We propose two distinct sporulation strategies used by C. botulinum Groups I-III strains, report their spore properties, and suggest a putative role for the exosporium in conferring high heat resistance. Strains within each physiological group produced spores with similar characteristics, likely reflecting adaptation to respective environmental habitats. Our work provides new information on the spores and on the population and single-cell level strategies in the sporulation of C. botulinum.
Subject: Clostridium botulinum
spore
exosporium
morphology
SPORE SURFACE
BACILLUS
AGGREGATION
INVOLVEMENT
NEUROTOXIN
MORPHOLOGY
BACTERIA
ADHESION
STRAINS
FOOD
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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