Early age exposure to moisture and mould is related to FeNO at the age of 6 years

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http://hdl.handle.net/10138/340428

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Tischer , C , Karvonen , A M , Kirjavainen , P V , Flexeder , C , Roponen , M , Hyvarinen , A , Renz , H , Frey , U P , Fuchs , O & Pekkanen , J 2021 , ' Early age exposure to moisture and mould is related to FeNO at the age of 6 years ' , Pediatric Allergy and Immunology , vol. 32 , no. 6 , pp. 1226-1237 . https://doi.org/10.1111/pai.13526

Title: Early age exposure to moisture and mould is related to FeNO at the age of 6 years
Author: Tischer, Christina; Karvonen, Anne M.; Kirjavainen, Pirkka V.; Flexeder, Claudia; Roponen, Marjut; Hyvarinen, Anne; Renz, Harald; Frey, Urs Peter; Fuchs, Oliver; Pekkanen, Juha
Contributor organization: Department of Public Health
University of Helsinki
Date: 2021-08
Language: eng
Number of pages: 12
Belongs to series: Pediatric Allergy and Immunology
ISSN: 0905-6157
DOI: https://doi.org/10.1111/pai.13526
URI: http://hdl.handle.net/10138/340428
Abstract: Background Exposure to indoor moisture damage and visible mold has been found to be associated with asthma and respiratory symptoms in several questionnaire-based studies by self-report. We aimed to define the prospective association between the early life exposure to residential moisture damage or mold and fractional exhaled nitric oxide (FeNO) and lung function parameters as objective markers for airway inflammation and asthma in 6-year-old children. Methods Home inspections were performed in children's homes when infants were on average 5 months old. At age 6 years, data on FeNO (n = 322) as well as lung function (n = 216) measurements were collected. Logistic regression and generalized additive models were used for statistical analyses. Results Early age major moisture damage and moisture damage or mold in the child's main living areas were significantly associated with increased FeNO levels (>75th percentile) at the age of 6 years (adjusted odds ratios, 95% confidence intervals, aOR (95% CI): 3.10 (1.35-7.07) and 3.16 (1.43-6.98), respectively. Effects were more pronounced in those who did not change residential address throughout the study period. For lung function, major structural damage within the whole home was associated with reduced FEV1 and FVC, but not with FEV1/FVC. No association with lung function was observed with early moisture damage or mold in the child's main living areas. Conclusion These results underline the importance of prevention and remediation efforts of moisture and mold-damaged buildings in order to avoid harmful effects within the vulnerable phase of the infants and children's immunologic development.
Subject: asthma
cohort study
exhaled NO
lung function
moisture damage
EXHALED NITRIC-OXIDE
LUNG-FUNCTION
INDOOR ENVIRONMENT
RESPIRATORY HEALTH
ALLERGIC DISEASES
ASTHMA
CHILDHOOD
SYMPTOMS
DAMAGE
CHILDREN
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: acceptedVersion


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